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The current status of biomarkers for predicting toxicity.
Campion S, Aubrecht J, Boekelheide K, Brewster DW, Vaidya VS, Anderson L, Burt D, Dere E, Hwang K, Pacheco S, Saikumar J, Schomaker S, Sigman M, Goodsaid F. Campion S, et al. Among authors: aubrecht j. Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1391-408. doi: 10.1517/17425255.2013.827170. Epub 2013 Aug 21. Expert Opin Drug Metab Toxicol. 2013. PMID: 23961847 Free PMC article. Review.
Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis.
Aleo MD, Aubrecht J, D Bonin P, Burt DA, Colangelo J, Luo L, Schomaker S, Swiss R, Kirby S, C Rigdon G, Dua P. Aleo MD, et al. Among authors: aubrecht j. Pharmacol Res Perspect. 2019 Feb;7(1):e00467. doi: 10.1002/prp2.467. Pharmacol Res Perspect. 2019. PMID: 30784208 Free PMC article. Clinical Trial.
Discovery of Dap-3 polymyxin analogues for the treatment of multidrug-resistant Gram-negative nosocomial infections.
Magee TV, Brown MF, Starr JT, Ackley DC, Abramite JA, Aubrecht J, Butler A, Crandon JL, Dib-Hajj F, Flanagan ME, Granskog K, Hardink JR, Huband MD, Irvine R, Kuhn M, Leach KL, Li B, Lin J, Luke DR, MacVane SH, Miller AA, McCurdy S, McKim JM Jr, Nicolau DP, Nguyen TT, Noe MC, O'Donnell JP, Seibel SB, Shen Y, Stepan AF, Tomaras AP, Wilga PC, Zhang L, Xu J, Chen JM. Magee TV, et al. Among authors: aubrecht j. J Med Chem. 2013 Jun 27;56(12):5079-93. doi: 10.1021/jm400416u. Epub 2013 Jun 18. J Med Chem. 2013. PMID: 23735048
Assessment of emerging biomarkers of liver injury in human subjects.
Schomaker S, Warner R, Bock J, Johnson K, Potter D, Van Winkle J, Aubrecht J. Schomaker S, et al. Among authors: aubrecht j. Toxicol Sci. 2013 Apr;132(2):276-83. doi: 10.1093/toxsci/kft009. Epub 2013 Jan 20. Toxicol Sci. 2013. PMID: 23339181
Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort.
Church RJ, Kullak-Ublick GA, Aubrecht J, Bonkovsky HL, Chalasani N, Fontana RJ, Goepfert JC, Hackman F, King NMP, Kirby S, Kirby P, Marcinak J, Ormarsdottir S, Schomaker SJ, Schuppe-Koistinen I, Wolenski F, Arber N, Merz M, Sauer JM, Andrade RJ, van Bömmel F, Poynard T, Watkins PB. Church RJ, et al. Among authors: aubrecht j. Hepatology. 2019 Feb;69(2):760-773. doi: 10.1002/hep.29802. Epub 2018 Jun 27. Hepatology. 2019. PMID: 29357190 Free PMC article.
99 results