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Page 1
Genomically recoded organisms expand biological functions.
Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ. Lajoie MJ, et al. Among authors: aerni hr. Science. 2013 Oct 18;342(6156):357-60. doi: 10.1126/science.1241459. Science. 2013. PMID: 24136966 Free PMC article.
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids.
Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, Isaacs FJ. Amiram M, et al. Among authors: aerni hr. Nat Biotechnol. 2015 Dec;33(12):1272-1279. doi: 10.1038/nbt.3372. Epub 2015 Nov 16. Nat Biotechnol. 2015. PMID: 26571098 Free PMC article.
MS-READ: Quantitative measurement of amino acid incorporation.
Mohler K, Aerni HR, Gassaway B, Ling J, Ibba M, Rinehart J. Mohler K, et al. Among authors: aerni hr. Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt B):3081-3088. doi: 10.1016/j.bbagen.2017.01.025. Epub 2017 Jan 24. Biochim Biophys Acta Gen Subj. 2017. PMID: 28130155 Free PMC article.
Transfer RNA misidentification scrambles sense codon recoding.
Krishnakumar R, Prat L, Aerni HR, Ling J, Merryman C, Glass JI, Rinehart J, Söll D. Krishnakumar R, et al. Among authors: aerni hr. Chembiochem. 2013 Oct 11;14(15):1967-72. doi: 10.1002/cbic.201300444. Epub 2013 Sep 2. Chembiochem. 2013. PMID: 24000185 Free PMC article.
Chemical Evolution of a Bacterial Proteome.
Hoesl MG, Oehm S, Durkin P, Darmon E, Peil L, Aerni HR, Rappsilber J, Rinehart J, Leach D, Söll D, Budisa N. Hoesl MG, et al. Among authors: aerni hr. Angew Chem Int Ed Engl. 2015 Aug 17;54(34):10030-4. doi: 10.1002/anie.201502868. Epub 2015 Jul 1. Angew Chem Int Ed Engl. 2015. PMID: 26136259 Free PMC article.
A Precision Engineered Interleukin-2 for Bolstering CD8+ T- and NK-cell Activity without Eosinophilia and Vascular Leak Syndrome in Nonhuman Primates.
Ma L, Acuff NV, Joseph IB, Ptacin JL, Caffaro CE, San Jose KM, Aerni HR, Carrio R, Byers AM, Herman RW, Pavlova Y, Pena MJ, Chen DB, Buetz C, Ismaili TK, Pham HV, Cucchetti M, Sassoon I, Koriazova LK, Leveque JA, Shawver LK, Mooney JM, Milla ME. Ma L, et al. Among authors: aerni hr. Cancer Res Commun. 2024 Oct 1;4(10):2799-2814. doi: 10.1158/2767-9764.CRC-24-0278. Cancer Res Commun. 2024. PMID: 39320047 Free PMC article.
A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism.
Ptacin JL, Ma L, Caffaro CE, Acuff NV, Germar K, Severy P, Qu Y, Vela JL, Cai X, San Jose KM, Aerni HR, Chen DB, Esche E, Ismaili TK, Herman R, Pavlova Y, Pena MJ, Nguyen J, Koriazova LK, Shawver LK, Joseph IB, Mooney J, Peakman M, Milla ME. Ptacin JL, et al. Among authors: aerni hr. Commun Med (Lond). 2024 Mar 26;4(1):58. doi: 10.1038/s43856-024-00485-z. Commun Med (Lond). 2024. PMID: 38532017 Free PMC article.
An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism.
Ptacin JL, Caffaro CE, Ma L, San Jose Gall KM, Aerni HR, Acuff NV, Herman RW, Pavlova Y, Pena MJ, Chen DB, Koriazova LK, Shawver LK, Joseph IB, Milla ME. Ptacin JL, et al. Among authors: aerni hr. Nat Commun. 2021 Aug 9;12(1):4785. doi: 10.1038/s41467-021-24987-9. Nat Commun. 2021. PMID: 34373459 Free PMC article.
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Gassaway BM, Cardone RL, Padyana AK, Petersen MC, Judd ET, Hayes S, Tong S, Barber KW, Apostolidi M, Abulizi A, Sheetz JB, Kshitiz, Aerni HR, Gross S, Kung C, Samuel VT, Shulman GI, Kibbey RG, Rinehart J. Gassaway BM, et al. Among authors: aerni hr. Cell Rep. 2019 Dec 10;29(11):3394-3404.e9. doi: 10.1016/j.celrep.2019.11.009. Cell Rep. 2019. PMID: 31825824 Free PMC article.
28 results