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Synthesis, structure activity relationship, radiolabeling and preclinical evaluation of high affinity ligands for the ion channel of the N-methyl-d-aspartate receptor as potential imaging probes for positron emission tomography.
Klein PJ, Christiaans JA, Metaxas A, Schuit RC, Lammertsma AA, van Berckel BN, Windhorst AD. Klein PJ, et al. Among authors: metaxas a. Bioorg Med Chem. 2015 Mar 1;23(5):1189-206. doi: 10.1016/j.bmc.2014.12.029. Epub 2014 Dec 24. Bioorg Med Chem. 2015. PMID: 25648682
Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[(11)C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors.
Christiaans JA, Klein PJ, Metaxas A, Kooijman EJ, Schuit RC, Leysen JE, Lammertsma AA, van Berckel BN, Windhorst AD. Christiaans JA, et al. Among authors: metaxas a. Nucl Med Biol. 2014 Sep;41(8):670-80. doi: 10.1016/j.nucmedbio.2014.04.131. Epub 2014 May 10. Nucl Med Biol. 2014. PMID: 24929961
Quantification of the novel N-methyl-d-aspartate receptor ligand [11C]GMOM in man.
van der Doef TF, Golla SSV, Klein PJ, Oropeza-Seguias GM, Schuit RC, Metaxas A, Jobse E, Schwarte LA, Windhorst AD, Lammertsma AA, van Berckel BNM, Boellaard R. van der Doef TF, et al. Among authors: metaxas a. J Cereb Blood Flow Metab. 2016 Jun;36(6):1111-21. doi: 10.1177/0271678X15608391. Epub 2015 Oct 5. J Cereb Blood Flow Metab. 2016. PMID: 26661185 Free PMC article.
Binding characterization of N-(2-chloro-5-thiomethylphenyl)-N'-(3-[3 H]3 methoxy phenyl)-N'-methylguanidine ([3 H]GMOM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.
Metaxas A, van Berckel BNM, Klein PJ, Verbeek J, Nash EC, Kooijman EJM, Renjaän VA, Golla SSV, Boellaard R, Christiaans JAM, Windhorst AD, Leysen JE. Metaxas A, et al. Pharmacol Res Perspect. 2019 Feb;7(1):e00458. doi: 10.1002/prp2.458. Pharmacol Res Perspect. 2019. PMID: 30784206 Free PMC article.
Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-d-aspartate receptor.
Klein PJ, Chomet M, Metaxas A, Christiaans JA, Kooijman E, Schuit RC, Lammertsma AA, van Berckel BN, Windhorst AD. Klein PJ, et al. Among authors: metaxas a. Eur J Med Chem. 2016 Aug 8;118:143-60. doi: 10.1016/j.ejmech.2016.04.022. Epub 2016 Apr 19. Eur J Med Chem. 2016. PMID: 27128179
Preclinical evaluation of [(18)F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors.
Golla SS, Klein PJ, Bakker J, Schuit RC, Christiaans JA, van Geest L, Kooijman EJ, Oropeza-Seguias GM, Langermans JA, Leysen JE, Boellaard R, Windhorst AD, van Berckel BN, Metaxas A. Golla SS, et al. Among authors: metaxas a. Nucl Med Biol. 2015 Feb;42(2):205-12. doi: 10.1016/j.nucmedbio.2014.09.006. Epub 2014 Sep 30. Nucl Med Biol. 2015. PMID: 25451213
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