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A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells.
Schumacher F, Florian S, Schnapper A, Monien BH, Mewis I, Schreiner M, Seidel A, Engst W, Glatt H. Schumacher F, et al. Among authors: seidel a. Arch Toxicol. 2014 Mar;88(3):823-36. doi: 10.1007/s00204-013-1149-7. Epub 2013 Oct 24. Arch Toxicol. 2014. PMID: 24154822
The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens.
Ehlers A, Florian S, Schumacher F, Meinl W, Lenze D, Hummel M, Heise T, Seidel A, Glatt H, Lampen A. Ehlers A, et al. Among authors: seidel a. Mol Nutr Food Res. 2015 Apr;59(4):685-97. doi: 10.1002/mnfr.201400707. Epub 2015 Feb 9. Mol Nutr Food Res. 2015. PMID: 25559983
515 results