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SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.
Damonte P, Sociali G, Parenti MD, Soncini D, Bauer I, Boero S, Grozio A, Holtey MV, Piacente F, Becherini P, Sanguineti R, Salis A, Damonte G, Cea M, Murone M, Poggi A, Nencioni A, Del Rio A, Bruzzone S. Damonte P, et al. Among authors: del rio a. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858. doi: 10.1016/j.bmc.2017.09.023. Epub 2017 Sep 19. Bioorg Med Chem. 2017. PMID: 28958848
Quinazolinedione SIRT6 inhibitors sensitize cancer cells to chemotherapeutics.
Sociali G, Galeno L, Parenti MD, Grozio A, Bauer I, Passalacqua M, Boero S, Donadini A, Millo E, Bellotti M, Sturla L, Damonte P, Puddu A, Ferroni C, Varchi G, Franceschi C, Ballestrero A, Poggi A, Bruzzone S, Nencioni A, Del Rio A. Sociali G, et al. Among authors: del rio a. Eur J Med Chem. 2015 Sep 18;102:530-9. doi: 10.1016/j.ejmech.2015.08.024. Epub 2015 Aug 14. Eur J Med Chem. 2015. PMID: 26310895
Rejuvenating sirtuins: the rise of a new family of cancer drug targets.
Bruzzone S, Parenti MD, Grozio A, Ballestrero A, Bauer I, Del Rio A, Nencioni A. Bruzzone S, et al. Among authors: del rio a. Curr Pharm Des. 2013;19(4):614-23. doi: 10.2174/138161213804581954. Curr Pharm Des. 2013. PMID: 23016857 Free PMC article. Review.
Discovery of novel and selective SIRT6 inhibitors.
Parenti MD, Grozio A, Bauer I, Galeno L, Damonte P, Millo E, Sociali G, Franceschi C, Ballestrero A, Bruzzone S, Del Rio A, Nencioni A. Parenti MD, et al. Among authors: del rio a. J Med Chem. 2014 Jun 12;57(11):4796-804. doi: 10.1021/jm500487d. Epub 2014 May 19. J Med Chem. 2014. PMID: 24785705
Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model.
Sociali G, Magnone M, Ravera S, Damonte P, Vigliarolo T, Von Holtey M, Vellone VG, Millo E, Caffa I, Cea M, Parenti MD, Del Rio A, Murone M, Mostoslavsky R, Grozio A, Nencioni A, Bruzzone S. Sociali G, et al. Among authors: del rio a. FASEB J. 2017 Jul;31(7):3138-3149. doi: 10.1096/fj.201601294R. Epub 2017 Apr 6. FASEB J. 2017. PMID: 28386046 Free PMC article.
Sirtuin 6 (SIRT6) is a sirtuin family member involved in a wide range of physiologic and disease processes, including cancer and glucose homeostasis. ...G., Millo, E., Caffa, I., Cea, M., Parenti, M. D., Del Rio, A., Murone, M., Mostoslavsky, R. …
Sirtuin 6 (SIRT6) is a sirtuin family member involved in a wide range of physiologic and disease processes, including cancer a …
Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery.
Ghanem MS, Caffa I, Del Rio A, Franco J, Parenti MD, Monacelli F, Cea M, Khalifa A, Nahimana A, Duchosal MA, Ravera S, Bertola N, Bruzzone S, Nencioni A, Piacente F. Ghanem MS, et al. Among authors: del rio a. Pharmaceuticals (Basel). 2022 Jul 10;15(7):848. doi: 10.3390/ph15070848. Pharmaceuticals (Basel). 2022. PMID: 35890147 Free PMC article.
Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.
Di Matteo M, Ammazzalorso A, Andreoli F, Caffa I, De Filippis B, Fantacuzzi M, Giampietro L, Maccallini C, Nencioni A, Parenti MD, Soncini D, Del Rio A, Amoroso R. Di Matteo M, et al. Among authors: del rio a. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3192-3194. doi: 10.1016/j.bmcl.2016.04.078. Epub 2016 Apr 28. Bioorg Med Chem Lett. 2016. PMID: 27161804
Selectivity hot-spots of sirtuin catalytic cores.
Parenti MD, Bruzzone S, Nencioni A, Del Rio A. Parenti MD, et al. Among authors: del rio a. Mol Biosyst. 2015 Aug;11(8):2263-72. doi: 10.1039/c5mb00205b. Mol Biosyst. 2015. PMID: 26061123
513 results