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Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.
Chang CP, Wu CH, Song JS, Chou MC, Wong YC, Lin Y, Yeh TK, Sadani AA, Ou MH, Chen KH, Chen PH, Kuo PC, Tseng CT, Chang KH, Tseng SL, Chao YS, Hung MS, Shia KS. Chang CP, et al. Among authors: chen ph, chen kh. J Med Chem. 2013 Dec 27;56(24):9920-33. doi: 10.1021/jm401158e. Epub 2013 Dec 4. J Med Chem. 2013. PMID: 24224693
Synthetic Lipid Biology.
Chen PB, Li XL, Baskin JM. Chen PB, et al. Chem Rev. 2025 Jan 13. doi: 10.1021/acs.chemrev.4c00761. Online ahead of print. Chem Rev. 2025. PMID: 39805091 Review.
Recipients of Early Liver Transplants for Alcohol-Related Liver Disease May Reside in Areas With Lower Social Vulnerability.
Flanary J, King EA, Baimaji F, Strauss AT, Welch N, Bellar A, Sherman CB, Hameed B, Khalili M, Dasarathy S, Cameron AM, Chen PH. Flanary J, et al. Among authors: chen ph. Gastro Hep Adv. 2024 Sep 2;4(1):100542. doi: 10.1016/j.gastha.2024.08.020. eCollection 2025. Gastro Hep Adv. 2024. PMID: 39802488 Free PMC article. Review. No abstract available.
1,600 results