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SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.
Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, Koepsell H, Thomson SC, Rieg T. Vallon V, et al. Among authors: thomson sc. Am J Physiol Renal Physiol. 2014 Jan;306(2):F194-204. doi: 10.1152/ajprenal.00520.2013. Epub 2013 Nov 13. Am J Physiol Renal Physiol. 2014. PMID: 24226524 Free PMC article.
Knockout of Na+-glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration.
Song P, Huang W, Onishi A, Patel R, Kim YC, van Ginkel C, Fu Y, Freeman B, Koepsell H, Thomson S, Liu R, Vallon V. Song P, et al. Am J Physiol Renal Physiol. 2019 Jul 1;317(1):F207-F217. doi: 10.1152/ajprenal.00120.2019. Epub 2019 May 15. Am J Physiol Renal Physiol. 2019. PMID: 31091127 Free PMC article.
SGLT2 mediates glucose reabsorption in the early proximal tubule.
Vallon V, Platt KA, Cunard R, Schroth J, Whaley J, Thomson SC, Koepsell H, Rieg T. Vallon V, et al. Among authors: thomson sc. J Am Soc Nephrol. 2011 Jan;22(1):104-12. doi: 10.1681/ASN.2010030246. Epub 2010 Jul 8. J Am Soc Nephrol. 2011. PMID: 20616166 Free PMC article.
126 results