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Page 1
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.
Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andrés D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, Mäser P, Barrett MP, Horn D, De Koning HP. Munday JC, et al. Among authors: eze aa. J Antimicrob Chemother. 2014 Mar;69(3):651-63. doi: 10.1093/jac/dkt442. Epub 2013 Nov 13. J Antimicrob Chemother. 2014. PMID: 24235095 Free PMC article.
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.
Teka IA, Kazibwe AJ, El-Sabbagh N, Al-Salabi MI, Ward CP, Eze AA, Munday JC, Mäser P, Matovu E, Barrett MP, de Koning HP. Teka IA, et al. Among authors: eze aa. Mol Pharmacol. 2011 Jul;80(1):110-6. doi: 10.1124/mol.111.071555. Epub 2011 Mar 24. Mol Pharmacol. 2011. PMID: 21436312 Free PMC article.
A new nonpolar N-hydroxy imidazoline lead compound with improved activity in a murine model of late-stage Trypanosoma brucei brucei infection is not cross-resistant with diamidines.
Ríos Martínez CH, Miller F, Ganeshamoorthy K, Glacial F, Kaiser M, de Koning HP, Eze AA, Lagartera L, Herraiz T, Dardonville C. Ríos Martínez CH, et al. Among authors: eze aa. Antimicrob Agents Chemother. 2015 Feb;59(2):890-904. doi: 10.1128/AAC.03958-14. Epub 2014 Nov 24. Antimicrob Agents Chemother. 2015. PMID: 25421467 Free PMC article.
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.
Munday JC, Tagoe DN, Eze AA, Krezdorn JA, Rojas López KE, Alkhaldi AA, McDonald F, Still J, Alzahrani KJ, Settimo L, De Koning HP. Munday JC, et al. Among authors: eze aa. Mol Microbiol. 2015 May;96(4):887-900. doi: 10.1111/mmi.12979. Epub 2015 Mar 21. Mol Microbiol. 2015. PMID: 25708978 Free PMC article.
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei.
Alghamdi AH, Munday JC, Campagnaro GD, Gurvic D, Svensson F, Okpara CE, Kumar A, Quintana J, Martin Abril ME, Milić P, Watson L, Paape D, Settimo L, Dimitriou A, Wielinska J, Smart G, Anderson LF, Woodley CM, Kelly SPY, Ibrahim HM, Hulpia F, Al-Salabi MI, Eze AA, Sprenger T, Teka IA, Gudin S, Weyand S, Field M, Dardonville C, Tidwell RR, Carrington M, O'Neill P, Boykin DW, Zachariae U, De Koning HP. Alghamdi AH, et al. Among authors: eze aa. Elife. 2020 Aug 11;9:e56416. doi: 10.7554/eLife.56416. Elife. 2020. PMID: 32762841 Free PMC article.
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake.
Munday JC, Rojas López KE, Eze AA, Delespaux V, Van Den Abbeele J, Rowan T, Barrett MP, Morrison LJ, de Koning HP. Munday JC, et al. Among authors: eze aa. Int J Parasitol Drugs Drug Resist. 2013 Feb 10;3:69-76. doi: 10.1016/j.ijpddr.2013.01.004. eCollection 2013 Dec. Int J Parasitol Drugs Drug Resist. 2013. PMID: 24533295 Free PMC article.
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy.
Alzahrani KJH, Ali JAM, Eze AA, Looi WL, Tagoe DNA, Creek DJ, Barrett MP, de Koning HP. Alzahrani KJH, et al. Among authors: eze aa. Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):206-226. doi: 10.1016/j.ijpddr.2017.04.003. Epub 2017 Apr 20. Int J Parasitol Drugs Drug Resist. 2017. PMID: 28453984 Free PMC article.
28 results