Williams JD - Search Results

1

Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.

Williams JD, Nguyen ST, Gu S, Ding X, Butler MM, Tashjian TF, Opperman TJ, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL. Williams JD, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7790-806. doi: 10.1016/j.bmc.2013.10.014. Epub 2013 Oct 25. Bioorg Med Chem. 2013. PMID: 24239389 Free PMC article.

2

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.

Williams JD, Khan AR, Harden EA, Hartline CB, Jefferson GM, Keith KA, Prichard MN, Zemlicka J, Peet NP, Bowlin TL. Williams JD, et al. Bioorg Med Chem. 2012 Jun 15;20(12):3710-8. doi: 10.1016/j.bmc.2012.04.049. Epub 2012 May 1. Bioorg Med Chem. 2012. PMID: 22607883 Free PMC article.

3

Small molecule inhibitors of anthrax lethal factor toxin.

Williams JD, Khan AR, Cardinale SC, Butler MM, Bowlin TL, Peet NP. Williams JD, et al. Bioorg Med Chem. 2014 Jan 1;22(1):419-34. doi: 10.1016/j.bmc.2013.11.009. Epub 2013 Nov 13. Bioorg Med Chem. 2014. PMID: 24290062 Free PMC article.

4

Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.

Nguyen ST, Williams JD, Butler MM, Ding X, Mills DM, Tashjian TF, Panchal RG, Weir SK, Moon C, Kim HO, Marsden JA, Peet NP, Bowlin TL. Nguyen ST, et al. Among authors: williams jd. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3366-72. doi: 10.1016/j.bmcl.2014.05.094. Epub 2014 Jun 12. Bioorg Med Chem Lett. 2014. PMID: 24969013 Free PMC article.

5

Synthesis and structure-activity relationships of novel phenoxyacetamide inhibitors of the Pseudomonas aeruginosa type III secretion system (T3SS).

Williams JD, Torhan MC, Neelagiri VR, Brown C, Bowlin NO, Di M, McCarthy CT, Aiello D, Peet NP, Bowlin TL, Moir DT. Williams JD, et al. Bioorg Med Chem. 2015 Mar 1;23(5):1027-43. doi: 10.1016/j.bmc.2015.01.011. Epub 2015 Jan 13. Bioorg Med Chem. 2015. PMID: 25638499 Free PMC article.

6

Structure-activity relationships of a novel pyranopyridine series of Gram-negative bacterial efflux pump inhibitors.

Nguyen ST, Kwasny SM, Ding X, Cardinale SC, McCarthy CT, Kim HS, Nikaido H, Peet NP, Williams JD, Bowlin TL, Opperman TJ. Nguyen ST, et al. Among authors: williams jd. Bioorg Med Chem. 2015 May 1;23(9):2024-34. doi: 10.1016/j.bmc.2015.03.016. Epub 2015 Mar 13. Bioorg Med Chem. 2015. PMID: 25818767 Free PMC article.

7

Synthesis and antifungal evaluation of head-to-head and head-to-tail bisamidine compounds.

Nguyen ST, Kwasny SM, Ding X, Williams JD, Peet NP, Bowlin TL, Opperman TJ. Nguyen ST, et al. Among authors: williams jd. Bioorg Med Chem. 2015 Sep 1;23(17):5789-98. doi: 10.1016/j.bmc.2015.07.006. Epub 2015 Jul 14. Bioorg Med Chem. 2015. PMID: 26209266 Free PMC article.

8

DNA Targeting as a Likely Mechanism Underlying the Antibacterial Activity of Synthetic Bis-Indole Antibiotics.

Opperman TJ, Kwasny SM, Li JB, Lewis MA, Aiello D, Williams JD, Peet NP, Moir DT, Bowlin TL, Long EC. Opperman TJ, et al. Among authors: williams jd. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7067-7076. doi: 10.1128/AAC.00309-16. Print 2016 Dec. Antimicrob Agents Chemother. 2016. PMID: 27620482 Free PMC article.

9

Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases.

Aiello D, Barnes MH, Biswas EE, Biswas SB, Gu S, Williams JD, Bowlin TL, Moir DT. Aiello D, et al. Among authors: williams jd. Bioorg Med Chem. 2009 Jul 1;17(13):4466-76. doi: 10.1016/j.bmc.2009.05.014. Epub 2009 May 12. Bioorg Med Chem. 2009. PMID: 19477652 Free PMC article.

10

Efflux-mediated bis-indole resistance in Staphylococcus aureus reveals differential substrate specificities for MepA and MepR.

Opperman TJ, Williams JD, Houseweart C, Panchal RG, Bavari S, Peet NP, Moir DT, Bowlin TL. Opperman TJ, et al. Among authors: williams jd. Bioorg Med Chem. 2010 Mar 15;18(6):2123-2130. doi: 10.1016/j.bmc.2010.02.005. Epub 2010 Feb 10. Bioorg Med Chem. 2010. PMID: 20188576

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