Bursen A - Search Results

1

Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells.

Montes R, Ayllón V, Prieto C, Bursen A, Prelle C, Romero-Moya D, Real PJ, Navarro-Montero O, Chillón C, Marschalek R, Bueno C, Menendez P. Montes R, et al. Among authors: bursen a. Leukemia. 2014 Mar;28(3):666-74. doi: 10.1038/leu.2013.346. Epub 2013 Nov 18. Leukemia. 2014. PMID: 24240202

2

Activated KRAS Cooperates with MLL-AF4 to Promote Extramedullary Engraftment and Migration of Cord Blood CD34+ HSPC But Is Insufficient to Initiate Leukemia.

Prieto C, Stam RW, Agraz-Doblas A, Ballerini P, Camos M, Castaño J, Marschalek R, Bursen A, Varela I, Bueno C, Menendez P. Prieto C, et al. Among authors: bursen a. Cancer Res. 2016 Apr 15;76(8):2478-89. doi: 10.1158/0008-5472.CAN-15-2769. Epub 2016 Feb 2. Cancer Res. 2016. PMID: 26837759

3

The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.

Benedikt A, Baltruschat S, Scholz B, Bursen A, Arrey TN, Meyer B, Varagnolo L, Müller AM, Karas M, Dingermann T, Marschalek R. Benedikt A, et al. Among authors: bursen a. Leukemia. 2011 Jan;25(1):135-44. doi: 10.1038/leu.2010.249. Epub 2010 Oct 29. Leukemia. 2011. PMID: 21030982

4

Expression of MLL-AF4 or AF4-MLL fusions does not impact the efficiency of DNA damage repair.

Castaño J, Herrero AB, Bursen A, González F, Marschalek R, Gutiérrez NC, Menendez P. Castaño J, et al. Among authors: bursen a. Oncotarget. 2016 May 24;7(21):30440-52. doi: 10.18632/oncotarget.8938. Oncotarget. 2016. PMID: 27119507 Free PMC article.

5

Secondary mutations in t(4;11) leukemia patients.

Prelle C, Bursen A, Dingermann T, Marschalek R. Prelle C, et al. Among authors: bursen a. Leukemia. 2013 Jun;27(6):1425-7. doi: 10.1038/leu.2012.365. Epub 2012 Dec 14. Leukemia. 2013. PMID: 23242105 Free PMC article. No abstract available.

6

Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.

Gaussmann A, Wenger T, Eberle I, Bursen A, Bracharz S, Herr I, Dingermann T, Marschalek R. Gaussmann A, et al. Among authors: bursen a. Oncogene. 2007 May 17;26(23):3352-63. doi: 10.1038/sj.onc.1210125. Epub 2006 Nov 27. Oncogene. 2007. PMID: 17130830

7

Transcription linked to recombination: a gene-internal promoter coincides with the recombination hot spot II of the human MLL gene.

Scharf S, Zech J, Bursen A, Schraets D, Oliver PL, Kliem S, Pfitzner E, Gillert E, Dingermann T, Marschalek R. Scharf S, et al. Among authors: bursen a. Oncogene. 2007 Mar 1;26(10):1361-71. doi: 10.1038/sj.onc.1209948. Epub 2006 Sep 18. Oncogene. 2007. PMID: 16983345

8

The AF4-MLL fusion transiently augments multilineage hematopoietic engraftment but is not sufficient to initiate leukemia in cord blood CD34⁺ cells.

Prieto C, Marschalek R, Kühn A, Bursen A, Bueno C, Menéndez P. Prieto C, et al. Among authors: bursen a. Oncotarget. 2017 Jul 26;8(47):81936-81941. doi: 10.18632/oncotarget.19567. eCollection 2017 Oct 10. Oncotarget. 2017. PMID: 29137234 Free PMC article.

9

The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

Bursen A, Schwabe K, Rüster B, Henschler R, Ruthardt M, Dingermann T, Marschalek R. Bursen A, et al. Blood. 2010 Apr 29;115(17):3570-9. doi: 10.1182/blood-2009-06-229542. Epub 2010 Mar 1. Blood. 2010. PMID: 20194896 Free article.

10

Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?

Bursen A, Moritz S, Gaussmann A, Moritz S, Dingermann T, Marschalek R. Bursen A, et al. Oncogene. 2004 Aug 19;23(37):6237-49. doi: 10.1038/sj.onc.1207837. Oncogene. 2004. PMID: 15221006

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