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Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.
Nat Commun. 2013;4:2802. doi: 10.1038/ncomms3802.
Nat Commun. 2013.
PMID: 24257095
Free article.
Potent heterocyclic ligands for human complement c3a receptor.
Reid RC, Yau MK, Singh R, Hamidon JK, Lim J, Stoermer MJ, Fairlie DP.
Reid RC, et al. Among authors: hamidon jk.
J Med Chem. 2014 Oct 23;57(20):8459-70. doi: 10.1021/jm500956p. Epub 2014 Oct 8.
J Med Chem. 2014.
PMID: 25259874
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Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a.
Lohman RJ, Hamidon JK, Reid RC, Rowley JA, Yau MK, Halili MA, Nielsen DS, Lim J, Wu KC, Loh Z, Do A, Suen JY, Iyer A, Fairlie DP.
Lohman RJ, et al. Among authors: hamidon jk.
Nat Commun. 2017 Aug 24;8(1):351. doi: 10.1038/s41467-017-00414-w.
Nat Commun. 2017.
PMID: 28839129
Free PMC article.
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Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity.
Rowley JA, Reid RC, Poon EKY, Wu KC, Lim J, Lohman RJ, Hamidon JK, Yau MK, Halili MA, Durek T, Iyer A, Fairlie DP.
Rowley JA, et al. Among authors: hamidon jk.
J Med Chem. 2020 Jan 23;63(2):529-541. doi: 10.1021/acs.jmedchem.9b00927. Epub 2020 Jan 7.
J Med Chem. 2020.
PMID: 31910011
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