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749 results

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Page 1
Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds.
Ruel R, L'Heureux A, Thibeault C, Lapointe P, Martel A, Qiao JX, Hua J, Price LA, Wu Q, Chang M, Zheng J, Huang CS, Wexler RR, Rehfuss R, Lam PY. Ruel R, et al. Among authors: martel a. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6825-8. doi: 10.1016/j.bmcl.2013.10.009. Epub 2013 Oct 11. Bioorg Med Chem Lett. 2013. PMID: 24269480
New azole antagonists with high affinity for the P2Y(1) receptor.
Ruel R, L'Heureux A, Thibeault C, Daris JP, Martel A, Price LA, Wu Q, Hua J, Wexler RR, Rehfuss R, Lam PY. Ruel R, et al. Among authors: martel a. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3519-22. doi: 10.1016/j.bmcl.2013.04.041. Epub 2013 Apr 25. Bioorg Med Chem Lett. 2013. PMID: 23668989
beta-alanine dipeptides as MC4R agonists.
Ruel R, Herpin TF, Iben L, Luo G, Martel A, Mason H, Mattson G, Poirier B, Ruediger EH, Shi D, Thibault C, Yu G, Antal Zimanyi I, Poindexter GS, Macor JE. Ruel R, et al. Among authors: martel a. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4341-4. doi: 10.1016/j.bmcl.2003.09.036. Bioorg Med Chem Lett. 2003. PMID: 14643322
Discovery and preclinical studies of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737), an in vivo active potent VEGFR-2 inhibitor.
Ruel R, Thibeault C, L'Heureux A, Martel A, Cai ZW, Wei D, Qian L, Barrish JC, Mathur A, D'Arienzo C, Hunt JT, Kamath A, Marathe P, Zhang Y, Derbin G, Wautlet B, Mortillo S, Jeyaseelan R Sr, Henley B, Tejwani R, Bhide RS, Trainor GL, Fargnoli J, Lombardo LJ. Ruel R, et al. Among authors: martel a. Bioorg Med Chem Lett. 2008 May 1;18(9):2985-9. doi: 10.1016/j.bmcl.2008.03.057. Epub 2008 Mar 22. Bioorg Med Chem Lett. 2008. PMID: 18395443
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.
Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ, Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM, Priestley ES, Marinier A. Miller MM, et al. Among authors: martel a. J Med Chem. 2019 Aug 22;62(16):7400-7416. doi: 10.1021/acs.jmedchem.9b00186. Epub 2019 Aug 5. J Med Chem. 2019. PMID: 31246024
Discovery of Two Novel Antiplatelet Clinical Candidates (BMS-986120 and BMS-986141) That Antagonize Protease-Activated Receptor 4.
Priestley ES, Banville J, Deon D, Dubé L, Gagnon M, Guy J, Lapointe P, Lavallée JF, Martel A, Plamondon S, Rémillard R, Ruediger E, Tremblay F, Posy SL, Guarino VR, Richter JM, Li J, Gupta A, Vetrichelvan M, Balapragalathan TJ, Mathur A, Hua J, Callejo M, Guay J, Sum CS, Cvijic ME, Watson C, Wong P, Yang J, Bouvier M, Gordon DA, Wexler RR, Marinier A. Priestley ES, et al. Among authors: martel a. J Med Chem. 2022 Jul 14;65(13):8843-8854. doi: 10.1021/acs.jmedchem.2c00359. Epub 2022 Jun 21. J Med Chem. 2022. PMID: 35729784
Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates.
Marinier A, Martel A, Bachand C, Plamondon S, Turmel B, Daris JP, Banville J, Lapointe P, Ouellet C, Dextraze P, Menard M, Wright JJ, Alford J, Lee D, Stanley P, Nair X, Todderud G, Tramposch KM. Marinier A, et al. Among authors: martel a. Bioorg Med Chem. 2001 Jun;9(6):1395-427. doi: 10.1016/s0968-0896(01)00015-3. Bioorg Med Chem. 2001. PMID: 11408160
Sulfated galactocerebrosides as potential antiinflammatory agents.
Marinier A, Martel A, Banville J, Bachand C, Remillard R, Lapointe P, Turmel B, Menard M, Harte WE Jr, Wright JJ, Todderud G, Tramposch KM, Bajorath J, Hollenbaugh D, Aruffo A. Marinier A, et al. Among authors: martel a. J Med Chem. 1997 Sep 26;40(20):3234-47. doi: 10.1021/jm9606960. J Med Chem. 1997. PMID: 9379443
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
Naidu BN, Sorenson ME, Patel M, Ueda Y, Banville J, Beaulieu F, Bollini S, Dicker IB, Higley H, Lin Z, Pajor L, Parker DD, Terry BJ, Zheng M, Martel A, Meanwell NA, Krystal M, Walker MA. Naidu BN, et al. Among authors: martel a. Bioorg Med Chem Lett. 2015 Feb 1;25(3):717-20. doi: 10.1016/j.bmcl.2014.11.060. Epub 2014 Nov 27. Bioorg Med Chem Lett. 2015. PMID: 25529736
749 results