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Page 1
Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists.
Wilson DM, Apps J, Bailey N, Bamford MJ, Beresford IJ, Brackenborough K, Briggs MA, Brough S, Calver AR, Crook B, Davis RK, Davis RP, Davis S, Dean DK, Harris L, Heslop T, Holland V, Jeffrey P, Panchal TA, Parr CA, Quashie N, Schogger J, Sehmi SS, Stean TO, Steadman JG, Trail B, Wald J, Worby A, Takle AK, Witherington J, Medhurst AD. Wilson DM, et al. Among authors: takle ak. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6890-6. doi: 10.1016/j.bmcl.2013.09.090. Epub 2013 Oct 5. Bioorg Med Chem Lett. 2013. PMID: 24269482
(1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors.
Bamford MJ, Alberti MJ, Bailey N, Davies S, Dean DK, Gaiba A, Garland S, Harling JD, Jung DK, Panchal TA, Parr CA, Steadman JG, Takle AK, Townsend JT, Wilson DM, Witherington J. Bamford MJ, et al. Among authors: takle ak. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3402-6. doi: 10.1016/j.bmcl.2005.05.021. Bioorg Med Chem Lett. 2005. PMID: 15950465
Pyridone derivatives as potent and selective VLA-4 integrin antagonists.
Witherington J, Bordas V, Gaiba A, Green PM, Naylor A, Parr N, Smith DG, Takle AK, Ward RW. Witherington J, et al. Among authors: takle ak. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2256-9. doi: 10.1016/j.bmcl.2006.01.025. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16455247
Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.
Witherington J, Blaney EL, Bordas V, Elliott RL, Gaiba A, Garton N, Green PM, Naylor A, Smith DG, Spalding DJ, Takle AK, Ward RW. Witherington J, et al. Among authors: takle ak. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5538-41. doi: 10.1016/j.bmcl.2006.08.044. Epub 2006 Aug 22. Bioorg Med Chem Lett. 2006. PMID: 16931004
Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation.
Witherington J, Abberley L, Briggs MA, Collis K, Dean DK, Gaiba A, King NP, Kraus H, Shuker N, Steadman JG, Takle AK, Sanger G, Wadsworth G, Butler S, McKay F, Muir A, Winborn K, Heightman TD. Witherington J, et al. Among authors: takle ak. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2203-5. doi: 10.1016/j.bmcl.2007.12.021. Epub 2007 Dec 15. Bioorg Med Chem Lett. 2008. PMID: 18316188
26 results