Hanessian S - Search Results

1

Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).

Fransson R, McCracken AN, Chen B, McMonigle RJ, Edinger AL, Hanessian S. Fransson R, et al. Among authors: hanessian s. ACS Med Chem Lett. 2013 Oct 10;4(10):969-73. doi: 10.1021/ml4002425. ACS Med Chem Lett. 2013. PMID: 24273632 Free PMC article.

2

Design and synthesis of matrix metalloproteinase inhibitors guided by molecular modeling. Picking the S(1) pocket using conformationally constrained inhibitors.

Hanessian S, MacKay DB, Moitessier N. Hanessian S, et al. J Med Chem. 2001 Sep 13;44(19):3074-82. doi: 10.1021/jm010096n. J Med Chem. 2001. PMID: 11543676

3

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics.

Hanessian S, Yun H, Hou Y, Yang G, Bayrakdarian M, Therrien E, Moitessier N, Roggo S, Veenstra S, Tintelnot-Blomley M, Rondeau JM, Ostermeier C, Strauss A, Ramage P, Paganetti P, Neumann U, Betschart C. Hanessian S, et al. J Med Chem. 2005 Aug 11;48(16):5175-90. doi: 10.1021/jm050142+. J Med Chem. 2005. PMID: 16078837

4

Structure-based design and synthesis of macroheterocyclic peptidomimetic inhibitors of the aspartic protease beta-site amyloid precursor protein cleaving enzyme (BACE).

Hanessian S, Yang G, Rondeau JM, Neumann U, Betschart C, Tintelnot-Blomley M. Hanessian S, et al. J Med Chem. 2006 Jul 27;49(15):4544-67. doi: 10.1021/jm060154a. J Med Chem. 2006. PMID: 16854060

5

Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.

Hanessian S, Charron G, Billich A, Guerini D. Hanessian S, et al. Bioorg Med Chem Lett. 2007 Jan 15;17(2):491-4. doi: 10.1016/j.bmcl.2006.10.014. Epub 2006 Oct 10. Bioorg Med Chem Lett. 2007. PMID: 17070046

6

Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.

Hanessian S, Szychowski J, Adhikari SS, Vasquez G, Kandasamy P, Swayze EE, Migawa MT, Ranken R, François B, Wirmer-Bartoschek J, Kondo J, Westhof E. Hanessian S, et al. J Med Chem. 2007 May 17;50(10):2352-69. doi: 10.1021/jm061200+. Epub 2007 Apr 26. J Med Chem. 2007. PMID: 17458946

7

Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.

Hanessian S, Auzzas L, Giannini G, Marzi M, Cabri W, Barbarino M, Vesci L, Pisano C. Hanessian S, et al. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. doi: 10.1016/j.bmcl.2007.09.014. Epub 2007 Sep 8. Bioorg Med Chem Lett. 2007. PMID: 17892933

8

Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs.

Hanessian S, Simard D, Bayrakdarian M, Therrien E, Nilsson I, Fjellström O. Hanessian S, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1972-6. doi: 10.1016/j.bmcl.2008.01.122. Epub 2008 Feb 7. Bioorg Med Chem Lett. 2008. PMID: 18289852

9

Total synthesis of (+)-ambruticin S: probing the pharmacophoric subunit.

Hanessian S, Focken T, Mi X, Oza R, Chen B, Ritson D, Beaudegnies R. Hanessian S, et al. J Org Chem. 2010 Aug 20;75(16):5601-18. doi: 10.1021/jo100956v. J Org Chem. 2010. PMID: 20704433

10

Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.

Auzzas L, Larsson A, Matera R, Baraldi A, Deschênes-Simard B, Giannini G, Cabri W, Battistuzzi G, Gallo G, Ciacci A, Vesci L, Pisano C, Hanessian S. Auzzas L, et al. Among authors: hanessian s. J Med Chem. 2010 Dec 9;53(23):8387-99. doi: 10.1021/jm101092u. Epub 2010 Nov 12. J Med Chem. 2010. PMID: 21073160

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