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Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.
Surivet JP, Zumbrunn C, Rueedi G, Hubschwerlen C, Bur D, Bruyère T, Locher H, Ritz D, Keck W, Seiler P, Kohl C, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Gaertner M, Delers J, Enderlin-Paput M, Boehme M. Surivet JP, et al. Among authors: bruyere t. J Med Chem. 2013 Sep 26;56(18):7396-415. doi: 10.1021/jm400963y. Epub 2013 Sep 11. J Med Chem. 2013. PMID: 23968485
Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.
Surivet JP, Zumbrunn C, Rueedi G, Bur D, Bruyère T, Locher H, Ritz D, Seiler P, Kohl C, Ertel EA, Hess P, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Kraemer S, Gaertner M, Delers J, Enderlin-Paput M, Weiss M, Sube R, Hadana H, Keck W, Hubschwerlen C. Surivet JP, et al. Among authors: bruyere t. J Med Chem. 2015 Jan 22;58(2):927-42. doi: 10.1021/jm501590q. Epub 2014 Dec 23. J Med Chem. 2015. PMID: 25494934
Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.
Surivet JP, Zumbrunn C, Bruyère T, Bur D, Kohl C, Locher HH, Seiler P, Ertel EA, Hess P, Enderlin-Paput M, Enderlin-Paput S, Gauvin JC, Mirre A, Hubschwerlen C, Ritz D, Rueedi G. Surivet JP, et al. Among authors: bruyere t. J Med Chem. 2017 May 11;60(9):3776-3794. doi: 10.1021/acs.jmedchem.6b01831. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28406300
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
Panchaud P, Bruyère T, Blumstein AC, Bur D, Chambovey A, Ertel EA, Gude M, Hubschwerlen C, Jacob L, Kimmerlin T, Pfeifer T, Prade L, Seiler P, Ritz D, Rueedi G. Panchaud P, et al. Among authors: bruyere t. J Med Chem. 2017 May 11;60(9):3755-3775. doi: 10.1021/acs.jmedchem.6b01834. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28406299
NMR solution structure of the pathogenesis-related protein P14a.
Fernández C, Szyperski T, Bruyère T, Ramage P, Mösinger E, Wüthrich K. Fernández C, et al. Among authors: bruyere t. J Mol Biol. 1997 Feb 28;266(3):576-93. doi: 10.1006/jmbi.1996.0772. J Mol Biol. 1997. PMID: 9067611
Pathogenesis-related PR-1 proteins are antifungal. Isolation and characterization of three 14-kilodalton proteins of tomato and of a basic PR-1 of tobacco with inhibitory activity against Phytophthora infestans.
Niderman T, Genetet I, Bruyère T, Gees R, Stintzi A, Legrand M, Fritig B, Mösinger E. Niderman T, et al. Among authors: bruyere t. Plant Physiol. 1995 May;108(1):17-27. doi: 10.1104/pp.108.1.17. Plant Physiol. 1995. PMID: 7784503 Free PMC article.
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