Alayash AI - Search Results

1

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

Belcher JD, Chen C, Nguyen J, Milbauer L, Abdulla F, Alayash AI, Smith A, Nath KA, Hebbel RP, Vercellotti GM. Belcher JD, et al. Among authors: alayash ai. Blood. 2014 Jan 16;123(3):377-90. doi: 10.1182/blood-2013-04-495887. Epub 2013 Nov 25. Blood. 2014. PMID: 24277079 Free PMC article.

2

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Schaer DJ, et al. Among authors: alayash ai. Blood. 2013 Feb 21;121(8):1276-84. doi: 10.1182/blood-2012-11-451229. Epub 2012 Dec 20. Blood. 2013. PMID: 23264591 Free PMC article. Review.

3

Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease.

Chintagari NR, Nguyen J, Belcher JD, Vercellotti GM, Alayash AI. Chintagari NR, et al. Among authors: alayash ai. Blood Cells Mol Dis. 2015 Mar;54(3):302-6. doi: 10.1016/j.bcmd.2014.12.001. Epub 2014 Dec 22. Blood Cells Mol Dis. 2015. PMID: 25582460 Free PMC article.

4

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function.

Shi PA, Choi E, Chintagari NR, Nguyen J, Guo X, Yazdanbakhsh K, Mohandas N, Alayash AI, Manci EA, Belcher JD, Vercellotti GM. Shi PA, et al. Among authors: alayash ai. Br J Haematol. 2016 Nov;175(4):714-723. doi: 10.1111/bjh.14280. Epub 2016 Aug 10. Br J Haematol. 2016. PMID: 27507623 Free PMC article.

5

Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles.

Jana S, Strader MB, Meng F, Hicks W, Kassa T, Tarandovskiy I, De Paoli S, Simak J, Heaven MR, Belcher JD, Vercellotti GM, Alayash AI. Jana S, et al. Among authors: alayash ai. JCI Insight. 2018 Nov 2;3(21):e120451. doi: 10.1172/jci.insight.120451. JCI Insight. 2018. PMID: 30385713 Free PMC article.

6

Oxidative pathways in the sickle cell and beyond.

Alayash AI. Alayash AI. Blood Cells Mol Dis. 2018 May;70:78-86. doi: 10.1016/j.bcmd.2017.05.009. Epub 2017 May 20. Blood Cells Mol Dis. 2018. PMID: 28554826 Free PMC article. Review.

7

Hemoglobin-Based Blood Substitutes and the Treatment of Sickle Cell Disease: More Harm than Help?

Alayash AI. Alayash AI. Biomolecules. 2017 Jan 4;7(1):2. doi: 10.3390/biom7010002. Biomolecules. 2017. PMID: 28054978 Free PMC article. Review.

8

Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.

Quezado ZMN, Kamimura S, Smith M, Wang X, Heaven MR, Jana S, Vogel S, Zerfas P, Combs CA, Almeida LEF, Li Q, Quezado M, Horkayne-Szakaly I, Kosinski PA, Yu S, Kapadnis U, Kung C, Dang L, Wakim P, Eaton WA, Alayash AI, Thein SL. Quezado ZMN, et al. Among authors: alayash ai. Blood Cells Mol Dis. 2022 Jul;95:102660. doi: 10.1016/j.bcmd.2022.102660. Epub 2022 Mar 12. Blood Cells Mol Dis. 2022. PMID: 35366607 Free PMC article.

9

Effects of cell-free hemoglobin on hypoxia-inducible factor (HIF-1alpha) and heme oxygenase (HO-1) expressions in endothelial cells subjected to hypoxia.

Yeh LH, Alayash AI. Yeh LH, et al. Among authors: alayash ai. Antioxid Redox Signal. 2004 Dec;6(6):944-53. doi: 10.1089/ars.2004.6.944. Antioxid Redox Signal. 2004. PMID: 15548892

10

Blood substitutes: why haven't we been more successful?

Alayash AI. Alayash AI. Trends Biotechnol. 2014 Apr;32(4):177-85. doi: 10.1016/j.tibtech.2014.02.006. Epub 2014 Mar 12. Trends Biotechnol. 2014. PMID: 24630491 Free PMC article. Review.

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