Kim DH - Search Results

1

(S)-tetrahydroisoquinoline alkaloid inhibits LPS-induced arachidonic acid release through downregulation of cPLA2 expression.

Choi JM, Choi YH, Kim SK, Ahn KH, Won JH, Lim JH, Jang YJ, Lee S, Kim DH, Kim DK. Choi JM, et al. Among authors: kim dh, kim dk, kim sk. Mol Cells. 2013 Nov;36(5):400-9. doi: 10.1007/s10059-013-0078-x. Epub 2013 Nov 14. Mol Cells. 2013. PMID: 24293010 Free PMC article.

2

CKD712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C.

Oh YJ, Youn JH, Min HJ, Kim DH, Lee SS, Choi IH, Shin JS. Oh YJ, et al. Among authors: kim dh. Int Immunopharmacol. 2011 Sep;11(9):1160-5. doi: 10.1016/j.intimp.2011.03.013. Epub 2011 Mar 30. Int Immunopharmacol. 2011. PMID: 21457762

3

CKD-712, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, Inhibits the NF-κB Activation and Augments Akt Activation during TLR4 Signaling.

Lee J, Yang EJ, Shin JS, Kim DH, Lee SS, Choi IH. Lee J, et al. Among authors: kim dh. Immune Netw. 2011 Dec;11(6):420-3. doi: 10.4110/in.2011.11.6.420. Epub 2011 Dec 31. Immune Netw. 2011. PMID: 22346785 Free PMC article.

4

HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.

Tsoyi K, Kim HJ, Shin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Yun-Choi HS, Lee JH, Seo HG, Chang KC. Tsoyi K, et al. Among authors: kim hj, kim dh. Cell Signal. 2008 Oct;20(10):1839-47. doi: 10.1016/j.cellsig.2008.06.012. Epub 2008 Jun 27. Cell Signal. 2008. PMID: 18634870

5

Identification of CKD-516: a potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

Lee J, Kim SJ, Choi H, Kim YH, Lim IT, Yang HM, Lee CS, Kang HR, Ahn SK, Moon SK, Kim DH, Lee S, Choi NS, Lee KJ. Lee J, et al. Among authors: kim yh, kim dh, kim sj. J Med Chem. 2010 Sep 9;53(17):6337-54. doi: 10.1021/jm1002414. J Med Chem. 2010. PMID: 20690624

6

Discovery of a potent tubulin polymerization inhibitor: synthesis and evaluation of water-soluble prodrugs of benzophenone analog.

Lee J, Bae S, Lee SH, Choi H, Kim YH, Kim SJ, Park GT, Moon SK, Kim DH, Lee S, Ahn SK, Choi NS, Lee KJ. Lee J, et al. Among authors: kim yh, kim dh, kim sj. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6327-30. doi: 10.1016/j.bmcl.2010.05.060. Epub 2010 May 20. Bioorg Med Chem Lett. 2010. PMID: 20850313

7

Effects of the anti-sepsis drug, (S)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (CKD-712), on mortality, inflammation, and organ injuries in rodent sepsis models.

Park JH, Hwang IC, Ha N, Lee S, Kim JM, Lee SS, Yu H, Lim IT, You JA, Kim DH. Park JH, et al. Among authors: kim jm, kim dh. Arch Pharm Res. 2011 Mar;34(3):485-94. doi: 10.1007/s12272-011-0318-6. Epub 2011 May 6. Arch Pharm Res. 2011. PMID: 21547682

8

A phase I pharmacokinetic and pharmacodynamic study of CKD-732, an antiangiogenic agent, in patients with refractory solid cancer.

Shin SJ, Jeung HC, Ahn JB, Rha SY, Roh JK, Park KS, Kim DH, Kim C, Chung HC. Shin SJ, et al. Among authors: kim dh, kim c. Invest New Drugs. 2010 Oct;28(5):650-8. doi: 10.1007/s10637-009-9287-8. Epub 2009 Jul 8. Invest New Drugs. 2010. PMID: 19585083 Clinical Trial.

9

Tolerability and pharmacokinetics of lobeglitazone (CKD-501), a peroxisome proliferator-activated receptor-γ agonist: a single- and multiple-dose, double-blind, randomized control study in healthy male Korean subjects.

Kim JW, Kim JR, Yi S, Shin KH, Shin HS, Yoon SH, Cho JY, Kim DH, Shin SG, Jang IJ, Yu KS. Kim JW, et al. Among authors: kim dh, kim jr. Clin Ther. 2011 Nov;33(11):1819-30. doi: 10.1016/j.clinthera.2011.09.023. Epub 2011 Nov 1. Clin Ther. 2011. PMID: 22047812 Clinical Trial.

10

Enhanced efficacy of CKD-516 in combination with doxorubicin: pre-clinical evaluation using a hepatocellular carcinoma xenograft model.

Kim YI, Kim KW, Lee HK, Park J, Chung JW, Youn H, Kim SJ, Kim DH, Tseng JC, Lee JM. Kim YI, et al. Among authors: kim dh, kim sj, kim kw. Anticancer Res. 2014 Apr;34(4):1715-22. Anticancer Res. 2014. PMID: 24692701

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