Connarn J - Search Results

1

Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.

Li X, Srinivasan SR, Connarn J, Ahmad A, Young ZT, Kabza AM, Zuiderweg ER, Sun D, Gestwicki JE. Li X, et al. Among authors: connarn j. ACS Med Chem Lett. 2013 Nov 14;4(11):1042-7. doi: 10.1021/ml400204n. ACS Med Chem Lett. 2013. PMID: 24312699 Free PMC article.

2

The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.

Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. Connarn JN, et al. J Biol Chem. 2014 Jan 31;289(5):2908-17. doi: 10.1074/jbc.M113.519421. Epub 2013 Dec 10. J Biol Chem. 2014. PMID: 24327656 Free PMC article.

3

Metabolism of bupropion by carbonyl reductases in liver and intestine.

Connarn JN, Zhang X, Babiskin A, Sun D. Connarn JN, et al. Drug Metab Dispos. 2015 Jul;43(7):1019-27. doi: 10.1124/dmd.115.063107. Epub 2015 Apr 22. Drug Metab Dispos. 2015. PMID: 25904761 Free PMC article.

4

Trastuzumab resistance induces EMT to transform HER2(+) PTEN(-) to a triple negative breast cancer that requires unique treatment options.

Burnett JP, Korkaya H, Ouzounova MD, Jiang H, Conley SJ, Newman BW, Sun L, Connarn JN, Chen CS, Zhang N, Wicha MS, Sun D. Burnett JP, et al. Among authors: connarn jn. Sci Rep. 2015 Nov 2;5:15821. doi: 10.1038/srep15821. Sci Rep. 2015. PMID: 26522776 Free PMC article.

5

Identification of non-reported bupropion metabolites in human plasma.

Connarn JN, Luo R, Windak J, Zhang X, Babiskin A, Kelly M, Harrington G, Ellingrod VL, Kamali M, McInnis M, Sun D. Connarn JN, et al. Biopharm Drug Dispos. 2016 Dec;37(9):550-560. doi: 10.1002/bdd.2046. Biopharm Drug Dispos. 2016. PMID: 27723114 Free PMC article.

6

Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer.

Sun L, Burnett J, Gasparyan M, Xu F, Jiang H, Lin CC, Myers I, Korkaya H, Liu Y, Connarn J, He H, Zhang N, Wicha MS, Sun D. Sun L, et al. Among authors: connarn j. Oncotarget. 2016 Aug 9;7(32):51408-51422. doi: 10.18632/oncotarget.9839. Oncotarget. 2016. PMID: 27285982 Free PMC article.

7

Pharmacokinetics and Pharmacogenomics of Bupropion in Three Different Formulations with Different Release Kinetics in Healthy Human Volunteers.

Connarn JN, Flowers S, Kelly M, Luo R, Ward KM, Harrington G, Moncion I, Kamali M, McInnis M, Feng MR, Ellingrod V, Babiskin A, Zhang X, Sun D. Connarn JN, et al. AAPS J. 2017 Sep;19(5):1513-1522. doi: 10.1208/s12248-017-0102-8. Epub 2017 Jul 6. AAPS J. 2017. PMID: 28685396 Clinical Trial.

8

Population Pharmacokinetics of Lenalidomide in Healthy Volunteers and Patients With Hematologic Malignancies.

Connarn JN, Hwang R, Gao Y, Palmisano M, Chen N. Connarn JN, et al. Clin Pharmacol Drug Dev. 2018 Jun;7(5):465-473. doi: 10.1002/cpdd.372. Epub 2017 Jul 19. Clin Pharmacol Drug Dev. 2018. PMID: 28724202

9

Modeling and simulation of the endogenous CYP3A induction marker 4β-hydroxycholesterol during enasidenib treatment.

Li Y, Connarn JN, Chen J, Tong Z, Palmisano M, Zhou S. Li Y, et al. Among authors: connarn jn. Clin Pharmacol. 2019 Feb 15;11:39-50. doi: 10.2147/CPAA.S192687. eCollection 2019. Clin Pharmacol. 2019. PMID: 30858735 Free PMC article.

10

CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production.

Gaur R, Mensah KA, Stricker J, Adams M, Parton A, Cedzik D, Connarn J, Thomas M, Horan G, Schafer P, Mair S, Palmisano M, Ramírez-Valle F. Gaur R, et al. Among authors: connarn j. Arthritis Res Ther. 2022 Aug 18;24(1):199. doi: 10.1186/s13075-022-02850-6. Arthritis Res Ther. 2022. PMID: 35982464 Free PMC article. Clinical Trial.

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