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Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.
Alvarez-Castelao B, Castaño JG. Alvarez-Castelao B, et al. Among authors: castano jg. Cell Mol Life Sci. 2011 Aug;68(15):2643-54. doi: 10.1007/s00018-010-0592-3. Epub 2010 Nov 20. Cell Mol Life Sci. 2011. PMID: 21103907 Free PMC article.
Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome.
Alvarez-Castelao B, Muñoz C, Sánchez I, Goethals M, Vandekerckhove J, Castaño JG. Alvarez-Castelao B, et al. Among authors: castano jg. Biochim Biophys Acta. 2012 Feb;1823(2):524-33. doi: 10.1016/j.bbamcr.2011.11.010. Epub 2011 Dec 8. Biochim Biophys Acta. 2012. PMID: 22173095 Free article.
alpha-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines.
Martìn-Clemente B, Alvarez-Castelao B, Mayo I, Sierra AB, Dìaz V, Milán M, Fariñas I, Gómez-Isla T, Ferrer I, Castaño JG. Martìn-Clemente B, et al. Among authors: castano jg. J Biol Chem. 2004 Dec 17;279(51):52984-90. doi: 10.1074/jbc.M409028200. Epub 2004 Oct 4. J Biol Chem. 2004. PMID: 15466467 Free article.
Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors.
Alvarez-Castelao B, Martín-Guerrero I, García-Orad Á, Castaño JG. Alvarez-Castelao B, et al. Among authors: castano jg. J Biol Chem. 2009 Oct 9;284(41):28253-28262. doi: 10.1074/jbc.M109.004101. Epub 2009 Aug 13. J Biol Chem. 2009. Retraction in: J Biol Chem. 2016 Apr 22;291(17):8985. doi: 10.1074/jbc.A109.004101 PMID: 19679666 Free PMC article. Retracted.
61 results