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Heme oxygenase-1 induction by (S)-enantiomer of YS-51 (YS-51S), a synthetic isoquinoline alkaloid, inhibits nitric oxide production and nuclear factor-kappaB translocation in ROS 17/2.8 cells activated with inflammatory stimulants.
Chaea HJ, Kim HR, Kang YJ, Hyun KC, Kim HJ, Seo HG, Lee JH, Yun-Choi HS, Chang KC. Chaea HJ, et al. Among authors: lee jh. Int Immunopharmacol. 2007 Dec 5;7(12):1559-68. doi: 10.1016/j.intimp.2007.07.023. Epub 2007 Aug 14. Int Immunopharmacol. 2007. PMID: 17920533
HO-1 and JAK-2/STAT-1 signals are involved in preferential inhibition of iNOS over COX-2 gene expression by newly synthesized tetrahydroisoquinoline alkaloid, CKD712, in cells activated with lipopolysacchride.
Tsoyi K, Kim HJ, Shin JS, Kim DH, Cho HJ, Lee SS, Ahn SK, Yun-Choi HS, Lee JH, Seo HG, Chang KC. Tsoyi K, et al. Among authors: lee jh, lee ss. Cell Signal. 2008 Oct;20(10):1839-47. doi: 10.1016/j.cellsig.2008.06.012. Epub 2008 Jun 27. Cell Signal. 2008. PMID: 18634870
Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo.
Tsoyi K, Lee TY, Lee YS, Kim HJ, Seo HG, Lee JH, Chang KC. Tsoyi K, et al. Among authors: lee ty, lee ys, lee jh. Mol Pharmacol. 2009 Jul;76(1):173-82. doi: 10.1124/mol.109.055137. Epub 2009 Apr 14. Mol Pharmacol. 2009. PMID: 19366789
Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction.
Tsoyi K, Jang HJ, Kim JW, Chang HK, Lee YS, Pae HO, Kim HJ, Seo HG, Lee JH, Chung HT, Chang KC. Tsoyi K, et al. Among authors: lee ys, lee jh. Antioxid Redox Signal. 2011 Jun;14(11):2057-70. doi: 10.1089/ars.2010.3555. Epub 2011 Mar 17. Antioxid Redox Signal. 2011. PMID: 21083424
β₁-adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice.
Ha YM, Ham SA, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Park MK, Chang KC. Ha YM, et al. Among authors: lee ys, lee jh. Biochem Pharmacol. 2011 Oct 1;82(7):769-77. doi: 10.1016/j.bcp.2011.06.041. Epub 2011 Jul 5. Biochem Pharmacol. 2011. PMID: 21763292
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