Shah F - Search Results

1

Analysis of Pfizer compounds in EPA's ToxCast chemicals-assay space.

Shah F, Greene N. Shah F, et al. Chem Res Toxicol. 2014 Jan 21;27(1):86-98. doi: 10.1021/tx400343t. Epub 2013 Dec 11. Chem Res Toxicol. 2014. PMID: 24328225

2

Finding the rules for successful drug optimisation.

Yusof I, Shah F, Hashimoto T, Segall MD, Greene N. Yusof I, et al. Among authors: shah f. Drug Discov Today. 2014 May;19(5):680-7. doi: 10.1016/j.drudis.2014.01.005. Epub 2014 Jan 19. Drug Discov Today. 2014. PMID: 24451293 Review.

3

Chemotypes sensitivity and predictivity of in vivo outcomes for cytotoxic assays in THLE and HepG2 cell lines.

Shah F, Louise-May S, Greene N. Shah F, et al. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2753-7. doi: 10.1016/j.bmcl.2014.04.039. Epub 2014 Apr 18. Bioorg Med Chem Lett. 2014. PMID: 24794102

4

Setting Clinical Exposure Levels of Concern for Drug-Induced Liver Injury (DILI) Using Mechanistic in vitro Assays.

Shah F, Leung L, Barton HA, Will Y, Rodrigues AD, Greene N, Aleo MD. Shah F, et al. Toxicol Sci. 2015 Oct;147(2):500-14. doi: 10.1093/toxsci/kfv152. Epub 2015 Jul 23. Toxicol Sci. 2015. PMID: 26206150

5

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Aleo MD, Shah F, He K, Bonin PD, Rodrigues AD. Aleo MD, et al. Among authors: shah f. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4. Chem Res Toxicol. 2017. PMID: 28437613

6

Moving beyond Binary Predictions of Human Drug-Induced Liver Injury (DILI) toward Contrasting Relative Risk Potential.

Aleo MD, Shah F, Allen S, Barton HA, Costales C, Lazzaro S, Leung L, Nilson A, Obach RS, Rodrigues AD, Will Y. Aleo MD, et al. Among authors: shah f. Chem Res Toxicol. 2020 Jan 21;33(1):223-238. doi: 10.1021/acs.chemrestox.9b00262. Epub 2019 Oct 7. Chem Res Toxicol. 2020. PMID: 31532188

7

Amine promiscuity and toxicology analysis.

Lee EC, Steeno G, Wassermann AM, Zhang L, Shah F, Price DA. Lee EC, et al. Among authors: shah f. Bioorg Med Chem Lett. 2017 Feb 1;27(3):653-657. doi: 10.1016/j.bmcl.2016.11.085. Epub 2016 Nov 29. Bioorg Med Chem Lett. 2017. PMID: 28011216

8

Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.

Shah F, Stepan AF, O'Mahony A, Velichko S, Folias AE, Houle C, Shaffer CL, Marcek J, Whritenour J, Stanton R, Berg EL. Shah F, et al. Cell Chem Biol. 2017 Jul 20;24(7):858-869.e5. doi: 10.1016/j.chembiol.2017.06.003. Epub 2017 Jun 29. Cell Chem Biol. 2017. PMID: 28669525 Free article.

9

The Identification of Pivotal Transcriptional Factors Mediating Cell Responses to Drugs With Drug-Induced Liver Injury Liabilities.

Shah F, Medvedev A, Wassermann AM, Brodney M, Zhang L, Makarov S, Stanton RV. Shah F, et al. Toxicol Sci. 2018 Mar 1;162(1):177-188. doi: 10.1093/toxsci/kfx231. Toxicol Sci. 2018. PMID: 29106686 Free PMC article.

10

Inhibitors of SARS-3CLpro: virtual screening, biological evaluation, and molecular dynamics simulation studies.

Mukherjee P, Shah F, Desai P, Avery M. Mukherjee P, et al. Among authors: shah f. J Chem Inf Model. 2011 Jun 27;51(6):1376-92. doi: 10.1021/ci1004916. Epub 2011 May 23. J Chem Inf Model. 2011. PMID: 21604711 Free PMC article.

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