Mak DH - Search Results

1

Apoptosis repressor with caspase recruitment domain is regulated by MAPK/PI3K and confers drug resistance and survival advantage to AML.

Mak PY, Mak DH, Mu H, Shi Y, Ruvolo P, Ruvolo V, Jacamo R, Burks JK, Wei W, Huang X, Kornblau SM, Andreeff M, Carter BZ. Mak PY, et al. Among authors: mak dh. Apoptosis. 2014 Apr;19(4):698-707. doi: 10.1007/s10495-013-0954-z. Apoptosis. 2014. PMID: 24337870 Free PMC article.

2

An ARC-Regulated IL1β/Cox-2/PGE2/β-Catenin/ARC Circuit Controls Leukemia-Microenvironment Interactions and Confers Drug Resistance in AML.

Carter BZ, Mak PY, Wang X, Tao W, Ruvolo V, Mak D, Mu H, Burks JK, Andreeff M. Carter BZ, et al. Cancer Res. 2019 Mar 15;79(6):1165-1177. doi: 10.1158/0008-5472.CAN-18-0921. Epub 2019 Jan 23. Cancer Res. 2019. PMID: 30674535 Free PMC article.

3

MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML.

Carter BZ, Mak DH, Shi Y, Fidler JM, Chen R, Ling X, Plunkett W, Andreeff M. Carter BZ, et al. Among authors: mak dh. Leukemia. 2012 Mar;26(3):443-50. doi: 10.1038/leu.2011.246. Epub 2011 Sep 9. Leukemia. 2012. PMID: 21904380 Free PMC article.

4

Combined inhibition of β-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo.

Zhou H, Mak PY, Mu H, Mak DH, Zeng Z, Cortes J, Liu Q, Andreeff M, Carter BZ. Zhou H, et al. Among authors: mak dh, mak py. Leukemia. 2017 Oct;31(10):2065-2074. doi: 10.1038/leu.2017.87. Epub 2017 Mar 21. Leukemia. 2017. PMID: 28321124 Free PMC article.

5

XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML.

Carter BZ, Mak DH, Morris SJ, Borthakur G, Estey E, Byrd AL, Konopleva M, Kantarjian H, Andreeff M. Carter BZ, et al. Among authors: mak dh. Apoptosis. 2011 Jan;16(1):67-74. doi: 10.1007/s10495-010-0545-1. Apoptosis. 2011. PMID: 20938744 Free PMC article. Clinical Trial.

6

Expression of ARC (apoptosis repressor with caspase recruitment domain), an antiapoptotic protein, is strongly prognostic in AML.

Carter BZ, Qiu YH, Zhang N, Coombes KR, Mak DH, Thomas DA, Ravandi F, Kantarjian HM, Koller E, Andreeff M, Kornblau SM. Carter BZ, et al. Among authors: mak dh. Blood. 2011 Jan 20;117(3):780-7. doi: 10.1182/blood-2010-04-280503. Epub 2010 Nov 1. Blood. 2011. PMID: 21041716 Free PMC article.

7

Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML.

Carter BZ, Qiu Y, Huang X, Diao L, Zhang N, Coombes KR, Mak DH, Konopleva M, Cortes J, Kantarjian HM, Mills GB, Andreeff M, Kornblau SM. Carter BZ, et al. Among authors: mak dh. Blood. 2012 Jul 5;120(1):173-80. doi: 10.1182/blood-2012-02-409888. Epub 2012 May 29. Blood. 2012. PMID: 22645176 Free PMC article.

8

XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells.

Carter BZ, Mak DH, Wang Z, Ma W, Mak PY, Andreeff M, Davis RE. Carter BZ, et al. Among authors: mak dh, mak py. Leuk Res. 2013 Aug;37(8):974-9. doi: 10.1016/j.leukres.2013.04.018. Epub 2013 May 10. Leuk Res. 2013. PMID: 23669290 Free PMC article.

9

Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents.

Carter BZ, Mak PY, Mak DH, Shi Y, Qiu Y, Bogenberger JM, Mu H, Tibes R, Yao H, Coombes KR, Jacamo RO, McQueen T, Kornblau SM, Andreeff M. Carter BZ, et al. Among authors: mak dh, mak py. J Natl Cancer Inst. 2014 Feb;106(2):djt440. doi: 10.1093/jnci/djt440. J Natl Cancer Inst. 2014. PMID: 24526787 Free PMC article.

10

Apoptosis repressor with caspase recruitment domain modulates second mitochondrial-derived activator of caspases mimetic-induced cell death through BIRC2/MAP3K14 signalling in acute myeloid leukaemia.

Mak PY, Mak DH, Ruvolo V, Jacamo R, Kornblau SM, Kantarjian H, Andreeff M, Carter BZ. Mak PY, et al. Among authors: mak dh. Br J Haematol. 2014 Nov;167(3):376-84. doi: 10.1111/bjh.13054. Epub 2014 Jul 31. Br J Haematol. 2014. PMID: 25079338 Free PMC article.

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