Gohlke H - Search Results

1

A membrane-proximal, C-terminal α-helix is required for plasma membrane localization and function of the G Protein-coupled receptor (GPCR) TGR5.

Spomer L, Gertzen CG, Schmitz B, Häussinger D, Gohlke H, Keitel V. Spomer L, et al. Among authors: gohlke h. J Biol Chem. 2014 Feb 7;289(6):3689-702. doi: 10.1074/jbc.M113.502344. Epub 2013 Dec 13. J Biol Chem. 2014. PMID: 24338481 Free PMC article.

2

Activation of integrins by urea in perfused rat liver.

Reinehr R, Gohlke H, Sommerfeld A, Vom Dahl S, Häussinger D. Reinehr R, et al. Among authors: gohlke h. J Biol Chem. 2010 Sep 17;285(38):29348-56. doi: 10.1074/jbc.M110.155135. Epub 2010 Jul 19. J Biol Chem. 2010. PMID: 20643649 Free PMC article.

3

α5 β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes.

Gohlke H, Schmitz B, Sommerfeld A, Reinehr R, Häussinger D. Gohlke H, et al. Hepatology. 2013 Mar;57(3):1117-29. doi: 10.1002/hep.25992. Epub 2012 Sep 17. Hepatology. 2013. PMID: 22865233

4

Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2.

Alchab F, Ettouati L, Bouaziz Z, Bollacke A, Delcros JG, Gertzen CG, Gohlke H, Pinaud N, Marchivie M, Guillon J, Fenet B, Jose J, Borgne ML. Alchab F, et al. Among authors: gohlke h. Pharmaceuticals (Basel). 2015 Jun 8;8(2):279-302. doi: 10.3390/ph8020279. Pharmaceuticals (Basel). 2015. PMID: 26061121 Free PMC article.

5

Mutational mapping of the transmembrane binding site of the G-protein coupled receptor TGR5 and binding mode prediction of TGR5 agonists.

Gertzen CG, Spomer L, Smits SH, Häussinger D, Keitel V, Gohlke H. Gertzen CG, et al. Among authors: gohlke h. Eur J Med Chem. 2015 Nov 2;104:57-72. doi: 10.1016/j.ejmech.2015.09.024. Epub 2015 Sep 24. Eur J Med Chem. 2015. PMID: 26435512

6

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies.

Frieg B, Görg B, Homeyer N, Keitel V, Häussinger D, Gohlke H. Frieg B, et al. Among authors: gohlke h. PLoS Comput Biol. 2016 Feb 2;12(2):e1004693. doi: 10.1371/journal.pcbi.1004693. eCollection 2016 Feb. PLoS Comput Biol. 2016. PMID: 26836257 Free PMC article.

7

Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors.

Zhang Z, Gu Q, Jaguva Vasudevan AA, Hain A, Kloke BP, Hasheminasab S, Mulnaes D, Sato K, Cichutek K, Häussinger D, Bravo IG, Smits SH, Gohlke H, Münk C. Zhang Z, et al. Among authors: gohlke h. Retrovirology. 2016 Jul 1;13(1):46. doi: 10.1186/s12977-016-0274-9. Retrovirology. 2016. PMID: 27368163 Free PMC article.

8

From Hansch-Fujita Analysis to AFMoC: A Road to Structure-Based QSAR.

Gertzen CG, Gohlke H. Gertzen CG, et al. Among authors: gohlke h. Mol Inform. 2012 Oct;31(10):698-704. doi: 10.1002/minf.201200015. Epub 2012 Aug 7. Mol Inform. 2012. PMID: 27476451

9

Structural assemblies of the di- and oligomeric G-protein coupled receptor TGR5 in live cells: an MFIS-FRET and integrative modelling study.

Greife A, Felekyan S, Ma Q, Gertzen CG, Spomer L, Dimura M, Peulen TO, Wöhler C, Häussinger D, Gohlke H, Keitel V, Seidel CA. Greife A, et al. Among authors: gohlke h. Sci Rep. 2016 Nov 11;6:36792. doi: 10.1038/srep36792. Sci Rep. 2016. PMID: 27833095 Free PMC article.

10

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.

Krieger V, Hamacher A, Gertzen CGW, Senger J, Zwinderman MRH, Marek M, Romier C, Dekker FJ, Kurz T, Jung M, Gohlke H, Kassack MU, Hansen FK. Krieger V, et al. Among authors: gohlke h. J Med Chem. 2017 Jul 13;60(13):5493-5506. doi: 10.1021/acs.jmedchem.7b00197. Epub 2017 Jun 16. J Med Chem. 2017. PMID: 28574690

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