Maxwell RJ - Search Results

1

The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice.

Haagensen EJ, Thomas HD, Wilson I, Harnor SJ, Payne SL, Rennison T, Smith KM, Maxwell RJ, Newell DR. Haagensen EJ, et al. Among authors: maxwell rj. PLoS One. 2013 Dec 10;8(12):e81763. doi: 10.1371/journal.pone.0081763. eCollection 2013. PLoS One. 2013. PMID: 24339963 Free PMC article.

2

Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent.

Haagensen EJ, Thomas HD, Mudd C, Tsonou E, Wiggins CM, Maxwell RJ, Moore JD, Newell DR. Haagensen EJ, et al. Among authors: maxwell rj. Eur J Cancer. 2016 Mar;56:69-76. doi: 10.1016/j.ejca.2015.12.012. Epub 2016 Jan 25. Eur J Cancer. 2016. PMID: 26820797

3

Enhanced anti-tumour activity of the combination of the novel MEK inhibitor WX-554 and the novel PI3K inhibitor WX-037.

Haagensen EJ, Thomas HD, Schmalix WA, Payne AC, Kevorkian L, Allen RA, Bevan P, Maxwell RJ, Newell DR. Haagensen EJ, et al. Among authors: maxwell rj. Cancer Chemother Pharmacol. 2016 Dec;78(6):1269-1281. doi: 10.1007/s00280-016-3186-4. Epub 2016 Nov 11. Cancer Chemother Pharmacol. 2016. PMID: 27837257 Free PMC article.

4

The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition.

Haagensen EJ, Kyle S, Beale GS, Maxwell RJ, Newell DR. Haagensen EJ, et al. Among authors: maxwell rj. Br J Cancer. 2012 Apr 10;106(8):1386-94. doi: 10.1038/bjc.2012.70. Epub 2012 Mar 13. Br J Cancer. 2012. PMID: 22415236 Free PMC article.

5

Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging.

Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, Sharma A, Blair H, Hide IG, Heidenreich O, Vormoor J, Maxwell RJ, Bacon CM. Vormoor B, et al. Among authors: maxwell rj. PLoS One. 2014 Jan 7;9(1):e85128. doi: 10.1371/journal.pone.0085128. eCollection 2014. PLoS One. 2014. PMID: 24409320 Free PMC article.

6

PARP inhibitor rucaparib induces changes in NAD levels in cells and liver tissues as assessed by MRS.

Almeida GS, Bawn CM, Galler M, Wilson I, Thomas HD, Kyle S, Curtin NJ, Newell DR, Maxwell RJ. Almeida GS, et al. Among authors: maxwell rj. NMR Biomed. 2017 Sep;30(9). doi: 10.1002/nbm.3736. Epub 2017 May 22. NMR Biomed. 2017. PMID: 28543772

7

In vivo and ex vivo magnetic resonance spectroscopy as applied to pharmacokinetic studies with anticancer agents: a review.

Newell DR, Maxwell RJ, Golding BT. Newell DR, et al. Among authors: maxwell rj. NMR Biomed. 1992 Sep-Oct;5(5):273-8. doi: 10.1002/nbm.1940050514. NMR Biomed. 1992. PMID: 1449968 Review.

8

19F nuclear magnetic resonance imaging of drug distribution in vivo: the disposition of an antifolate anticancer drug in mice.

Maxwell RJ, Frenkiel TA, Newell DR, Bauer C, Griffiths JR. Maxwell RJ, et al. Magn Reson Med. 1991 Jan;17(1):189-96. doi: 10.1002/mrm.1910170122. Magn Reson Med. 1991. PMID: 2067393

9

Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells.

Lin H, Patel S, Affleck VS, Wilson I, Turnbull DM, Joshi AR, Maxwell R, Stoll EA. Lin H, et al. Neuro Oncol. 2017 Jan;19(1):43-54. doi: 10.1093/neuonc/now128. Epub 2016 Jun 29. Neuro Oncol. 2017. PMID: 27365097 Free PMC article.

10

Pharmacokinetic studies with the antifolate C2-desamino-C2-methyl-N10-propargyl-2'-trifluoromethyl-5,8-dideazafolic acid (CB3988) in mice and rats using in vivo 19F-NMR spectroscopy.

Newell DR, Maxwell RJ, Bisset GM, Jodrell DI, Griffiths JR. Newell DR, et al. Among authors: maxwell rj. Br J Cancer. 1990 Nov;62(5):766-72. doi: 10.1038/bjc.1990.376. Br J Cancer. 1990. PMID: 2245168 Free PMC article.

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