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Balancing novelty with confined chemical space in modern drug discovery.
Medina-Franco JL, Martinez-Mayorga K, Meurice N. Medina-Franco JL, et al. Among authors: meurice n. Expert Opin Drug Discov. 2014 Feb;9(2):151-65. doi: 10.1517/17460441.2014.872624. Epub 2013 Dec 19. Expert Opin Drug Discov. 2014. PMID: 24350718 Review.
Synthesis and highly potent hypolipidemic activity of alpha-asarone- and fibrate-based 2-acyl and 2-alkyl phenols as HMG-CoA reductase inhibitors.
Mendieta A, Jiménez F, Garduño-Siciliano L, Mojica-Villegas A, Rosales-Acosta B, Villa-Tanaca L, Chamorro-Cevallos G, Medina-Franco JL, Meurice N, Gutiérrez RU, Montiel LE, Cruz Mdel C, Tamariz J. Mendieta A, et al. Among authors: meurice n. Bioorg Med Chem. 2014 Nov 1;22(21):5871-82. doi: 10.1016/j.bmc.2014.09.022. Epub 2014 Sep 19. Bioorg Med Chem. 2014. PMID: 25311563
Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA Antibodies.
VanPatten S, Sun S, He M, Cheng KF, Altiti A, Papatheodorou A, Kowal C, Jeganathan V, Crawford JM, Bloom O, Volpe BT, Grant C, Meurice N, Coleman TR, Diamond B, Al-Abed Y. VanPatten S, et al. Among authors: meurice n. J Med Chem. 2016 Oct 13;59(19):8859-8867. doi: 10.1021/acs.jmedchem.6b00694. Epub 2016 Sep 20. J Med Chem. 2016. PMID: 27603688 Free PMC article.
Softening the Rule of Five--where to draw the line?
Petit J, Meurice N, Kaiser C, Maggiora G. Petit J, et al. Among authors: meurice n. Bioorg Med Chem. 2012 Sep 15;20(18):5343-51. doi: 10.1016/j.bmc.2011.11.064. Epub 2011 Dec 17. Bioorg Med Chem. 2012. PMID: 22222160 Free PMC article.
Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple Myeloma.
Welsh SJ, Barwick BG, Meermeier EW, Riggs DL, Shi CX, Zhu YX, Sharik ME, Du MT, Abrego Rocha LD, Garbitt VM, Stein CK, Petit JL, Meurice N, Tafoya Alvarado Y, Fonseca R, Todd KT, Brown S, Hammond ZJ, Cuc NH, Wittenberg C, Herzog C, Roschke AV, Demchenko YN, Chen WD, Li P, Liao W, Leonard WJ, Lonial S, Bahlis NJ, Neri P, Boise LH, Chesi M, Bergsagel PL. Welsh SJ, et al. Among authors: meurice n. Blood Cancer Discov. 2024 Jan 8;5(1):34-55. doi: 10.1158/2643-3230.BCD-23-0062. Blood Cancer Discov. 2024. PMID: 37767768 Free PMC article.
Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.
Olson TL, Zhang S, Labban D, Kaschner E, Aceves M, Iyer S, Meza-Aguilar JD, Zook JD, Chun E, Craciunescu FM, Liu W, Shi CX, Stewart AK, Hansen DT, Meurice N, Fromme P. Olson TL, et al. Among authors: meurice n. Protein Expr Purif. 2021 Sep;185:105890. doi: 10.1016/j.pep.2021.105890. Epub 2021 May 7. Protein Expr Purif. 2021. PMID: 33971243
39 results