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Functional characterization of a novel frameshift mutation in the C-terminus of the Nav1.5 channel underlying a Brugada syndrome with variable expression in a Spanish family.
Dolz-Gaitón P, Núñez M, Núñez L, Barana A, Amorós I, Matamoros M, Pérez-Hernández M, González de la Fuente M, Alvarez-López M, Macías-Ruiz R, Tercedor-Sánchez L, Jiménez-Jáimez J, Delpón E, Caballero R, Tamargo J. Dolz-Gaitón P, et al. Among authors: barana a. PLoS One. 2013 Nov 25;8(11):e81493. doi: 10.1371/journal.pone.0081493. eCollection 2013. PLoS One. 2013. PMID: 24363796 Free PMC article.
Functional effects of a missense mutation in HERG associated with type 2 long QT syndrome.
Amorós I, Jiménez-Jáimez J, Tercedor L, Barana A, Gómez R, de la Fuente MG, Dolz-Gaitón P, Alvarez M, Martínez-Espín E, Lorente JA, Melgares R, Tamargo J, Delpón E, Caballero R. Amorós I, et al. Among authors: barana a. Heart Rhythm. 2011 Mar;8(3):463-70. doi: 10.1016/j.hrthm.2010.11.032. Epub 2010 Nov 23. Heart Rhythm. 2011. PMID: 21109023
Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels.
Matamoros M, Pérez-Hernández M, Guerrero-Serna G, Amorós I, Barana A, Núñez M, Ponce-Balbuena D, Sacristán S, Gómez R, Tamargo J, Caballero R, Jalife J, Delpón E. Matamoros M, et al. Among authors: barana a. Cardiovasc Res. 2016 May 15;110(2):279-90. doi: 10.1093/cvr/cvw009. Epub 2016 Jan 19. Cardiovasc Res. 2016. PMID: 26786162 Free PMC article.
In humans, chronic atrial fibrillation decreases the transient outward current and ultrarapid component of the delayed rectifier current differentially on each atria and increases the slow component of the delayed rectifier current in both.
Caballero R, de la Fuente MG, Gómez R, Barana A, Amorós I, Dolz-Gaitón P, Osuna L, Almendral J, Atienza F, Fernández-Avilés F, Pita A, Rodríguez-Roda J, Pinto A, Tamargo J, Delpón E. Caballero R, et al. Among authors: barana a. J Am Coll Cardiol. 2010 May 25;55(21):2346-54. doi: 10.1016/j.jacc.2010.02.028. J Am Coll Cardiol. 2010. PMID: 20488306 Free article.
Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification.
Caballero R, Dolz-Gaitón P, Gómez R, Amorós I, Barana A, González de la Fuente M, Osuna L, Duarte J, López-Izquierdo A, Moraleda I, Gálvez E, Sánchez-Chapula JA, Tamargo J, Delpón E. Caballero R, et al. Among authors: barana a. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15631-6. doi: 10.1073/pnas.1004021107. Epub 2010 Aug 16. Proc Natl Acad Sci U S A. 2010. PMID: 20713726 Free PMC article.
Chronic atrial fibrillation up-regulates β1-Adrenoceptors affecting repolarizing currents and action potential duration.
González de la Fuente M, Barana A, Gómez R, Amorós I, Dolz-Gaitón P, Sacristán S, Atienza F, Pita A, Pinto Á, Fernández-Avilés F, Caballero R, Tamargo J, Delpón E. González de la Fuente M, et al. Among authors: barana a. Cardiovasc Res. 2013 Feb 1;97(2):379-88. doi: 10.1093/cvr/cvs313. Epub 2012 Oct 11. Cardiovasc Res. 2013. PMID: 23060133
25 results