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Rheb GTPase regulates β-secretase levels and amyloid β generation.
Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S. Shahani N, et al. J Biol Chem. 2014 Feb 28;289(9):5799-808. doi: 10.1074/jbc.M113.532713. Epub 2013 Dec 24. J Biol Chem. 2014. PMID: 24368770 Free PMC article.
Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade.
Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S. Tyagi R, et al. Among authors: shahani n. Cell Rep. 2015 Feb 10;10(5):684-693. doi: 10.1016/j.celrep.2015.01.014. Epub 2015 Feb 7. Cell Rep. 2015. PMID: 25660019 Free PMC article.
DISC1 regulates trafficking and processing of APP and Aβ generation.
Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A. Shahani N, et al. Mol Psychiatry. 2015 Jul;20(7):874-9. doi: 10.1038/mp.2014.100. Epub 2014 Sep 16. Mol Psychiatry. 2015. PMID: 25224257 Free PMC article.
RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson's disease.
Eshraghi M, Ramírez-Jarquín UN, Shahani N, Nuzzo T, De Rosa A, Swarnkar S, Galli N, Rivera O, Tsaprailis G, Scharager-Tapia C, Crynen G, Li Q, Thiolat ML, Bezard E, Usiello A, Subramaniam S. Eshraghi M, et al. Among authors: shahani n. Sci Adv. 2020 May 1;6(18):eaaz7001. doi: 10.1126/sciadv.aaz7001. eCollection 2020 May. Sci Adv. 2020. PMID: 32426479 Free PMC article.
44 results