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Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases.
Sun S, Zhang Z, Kodumuru V, Pokrovskaia N, Fonarev J, Jia Q, Leung PY, Tran J, Ratkay LG, McLaren DG, Radomski C, Chowdhury S, Fu J, Hubbard B, Winther MD, Dales NA. Sun S, et al. Among authors: kodumuru v. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5. doi: 10.1016/j.bmcl.2013.12.036. Epub 2013 Dec 16. Bioorg Med Chem Lett. 2014. PMID: 24374272
Discovery of benzylisothioureas as potent divalent metal transporter 1 (DMT1) inhibitors.
Zhang Z, Kodumuru V, Sviridov S, Liu S, Chafeev M, Chowdhury S, Chakka N, Sun J, Gauthier SJ, Mattice M, Ratkay LG, Kwan R, Thompson J, Cutts AB, Fu J, Kamboj R, Goldberg YP, Cadieux JA. Zhang Z, et al. Among authors: kodumuru v. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5108-13. doi: 10.1016/j.bmcl.2012.05.129. Epub 2012 Jun 15. Bioorg Med Chem Lett. 2012. PMID: 22749870
Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome.
Zhang Z, Sun S, Kodumuru V, Hou D, Liu S, Chakka N, Sviridov S, Chowdhury S, McLaren DG, Ratkay LG, Khakh K, Cheng X, Gschwend HW, Kamboj R, Fu J, Winther MD. Zhang Z, et al. Among authors: kodumuru v. J Med Chem. 2013 Jan 24;56(2):568-83. doi: 10.1021/jm301661h. Epub 2013 Jan 7. J Med Chem. 2013. PMID: 23245208