Brooke DG - Search Results

1

Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3).

Brooke DG, van Dam EM, Watts CK, Khoury A, Dziadek MA, Brooks H, Graham LJ, Flanagan JU, Denny WA. Brooke DG, et al. Bioorg Med Chem. 2014 Feb 1;22(3):1029-39. doi: 10.1016/j.bmc.2013.12.041. Epub 2013 Dec 30. Bioorg Med Chem. 2014. PMID: 24398380

2

A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.

Datta J, Ghoshal K, Denny WA, Gamage SA, Brooke DG, Phiasivongsa P, Redkar S, Jacob ST. Datta J, et al. Among authors: brooke dg. Cancer Res. 2009 May 15;69(10):4277-85. doi: 10.1158/0008-5472.CAN-08-3669. Epub 2009 May 5. Cancer Res. 2009. Retraction in: Cancer Res. 2023 Dec 15;83(24):4180. doi: 10.1158/0008-5472.CAN-23-2366 PMID: 19417133 Free PMC article. Retracted.

3

Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells.

Brooke DG, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ. Brooke DG, et al. Bioorg Med Chem. 2011 Dec 1;19(23):7033-43. doi: 10.1016/j.bmc.2011.10.006. Epub 2011 Oct 13. Bioorg Med Chem. 2011. PMID: 22044656

4

3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase AKR1C3.

Jamieson SM, Brooke DG, Heinrich D, Atwell GJ, Silva S, Hamilton EJ, Turnbull AP, Rigoreau LJ, Trivier E, Soudy C, Samlal SS, Owen PJ, Schroeder E, Raynham T, Flanagan JU, Denny WA. Jamieson SM, et al. Among authors: brooke dg. J Med Chem. 2012 Sep 13;55(17):7746-58. doi: 10.1021/jm3007867. Epub 2012 Aug 21. J Med Chem. 2012. PMID: 22877157

5

Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1.

Gamage SA, Brooke DG, Redkar S, Datta J, Jacob ST, Denny WA. Gamage SA, et al. Among authors: brooke dg. Bioorg Med Chem. 2013 Jun 1;21(11):3147-53. doi: 10.1016/j.bmc.2013.03.033. Epub 2013 Apr 6. Bioorg Med Chem. 2013. PMID: 23639684

6

Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-β-hydroxysteroid dehydrogenase (AKR1C3).

Flanagan JU, Atwell GJ, Heinrich DM, Brooke DG, Silva S, Rigoreau LJ, Trivier E, Turnbull AP, Raynham T, Jamieson SM, Denny WA. Flanagan JU, et al. Among authors: brooke dg. Bioorg Med Chem. 2014 Feb 1;22(3):967-77. doi: 10.1016/j.bmc.2013.12.050. Epub 2014 Jan 2. Bioorg Med Chem. 2014. PMID: 24411201

7

The Activity of SN33638, an Inhibitor of AKR1C3, on Testosterone and 17β-Estradiol Production and Function in Castration-Resistant Prostate Cancer and ER-Positive Breast Cancer.

Yin YD, Fu M, Brooke DG, Heinrich DM, Denny WA, Jamieson SM. Yin YD, et al. Among authors: brooke dg. Front Oncol. 2014 Jun 18;4:159. doi: 10.3389/fonc.2014.00159. eCollection 2014. Front Oncol. 2014. PMID: 24995161 Free PMC article.

8

Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs.

Field JJ, Kanakkanthara A, Brooke DG, Sinha S, Pillai SD, Denny WA, Butt AJ, Miller JH. Field JJ, et al. Among authors: brooke dg. Invest New Drugs. 2016 Jun;34(3):277-89. doi: 10.1007/s10637-016-0341-z. Epub 2016 Mar 12. Invest New Drugs. 2016. PMID: 26968704

9

Synthesis and Microtubule-Destabilizing Activity of N-Cyclopropyl-4-((3,4-dihydroquinolin-1(2H)-yl)sulfonyl)benzamide and its Analogs.

Field JJ, Singh AJ, Sinha S, Rowe MR, Denny WA, Brooke DG, Miller JH. Field JJ, et al. Among authors: brooke dg. Chem Asian J. 2019 Apr 15;14(8):1151-1157. doi: 10.1002/asia.201801313. Epub 2018 Nov 14. Chem Asian J. 2019. PMID: 30311418

10

Retraction: A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation.

Datta J, Ghoshal K, Denny WA, Gamage SA, Brooke DG, Phiasivongsa P, Redkar S, Jacob ST. Datta J, et al. Among authors: brooke dg. Cancer Res. 2023 Dec 15;83(24):4180. doi: 10.1158/0008-5472.CAN-23-2366. Cancer Res. 2023. PMID: 38098454 Free PMC article. No abstract available.

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