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The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death.
Xu J, Eriksson SE, Cebula M, Sandalova T, Hedström E, Pader I, Cheng Q, Myers CR, Antholine WE, Nagy P, Hellman U, Selivanova G, Lindqvist Y, Arnér ES. Xu J, et al. Cell Death Dis. 2015 Jan 22;6(1):e1616. doi: 10.1038/cddis.2014.574. Cell Death Dis. 2015. PMID: 25611390 Free PMC article.
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