Lehtimäki M - Search Results

1

Atomic resolution view into the structure-function relationships of the human myelin peripheral membrane protein P2.

Ruskamo S, Yadav RP, Sharma S, Lehtimäki M, Laulumaa S, Aggarwal S, Simons M, Bürck J, Ulrich AS, Juffer AH, Kursula I, Kursula P. Ruskamo S, et al. Among authors: lehtimaki m. Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):165-76. doi: 10.1107/S1399004713027910. Epub 2013 Dec 31. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 24419389 Free PMC article.

2

Production and crystallization of a panel of structure-based mutants of the human myelin peripheral membrane protein P2.

Lehtimäki M, Laulumaa S, Ruskamo S, Kursula P. Lehtimäki M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1;68(Pt 11):1359-62. doi: 10.1107/S1744309112039036. Epub 2012 Oct 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 23143249 Free PMC article.

3

Dynamics of the Peripheral Membrane Protein P2 from Human Myelin Measured by Neutron Scattering--A Comparison between Wild-Type Protein and a Hinge Mutant.

Laulumaa S, Nieminen T, Lehtimäki M, Aggarwal S, Simons M, Koza MM, Vattulainen I, Kursula P, Natali F. Laulumaa S, et al. Among authors: lehtimaki m. PLoS One. 2015 Jun 11;10(6):e0128954. doi: 10.1371/journal.pone.0128954. eCollection 2015. PLoS One. 2015. PMID: 26068118 Free PMC article.

4

Crystallographic analysis of the reaction cycle of 2',3'-cyclic nucleotide 3'-phosphodiesterase, a unique member of the 2H phosphoesterase family.

Myllykoski M, Raasakka A, Lehtimäki M, Han H, Kursula I, Kursula P. Myllykoski M, et al. Among authors: lehtimaki m. J Mol Biol. 2013 Nov 15;425(22):4307-22. doi: 10.1016/j.jmb.2013.06.012. Epub 2013 Jul 2. J Mol Biol. 2013. PMID: 23831225 Free PMC article.

5

Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase.

Raasakka A, Myllykoski M, Laulumaa S, Lehtimäki M, Härtlein M, Moulin M, Kursula I, Kursula P. Raasakka A, et al. Among authors: lehtimaki m. Sci Rep. 2015 Nov 13;5:16520. doi: 10.1038/srep16520. Sci Rep. 2015. PMID: 26563764 Free PMC article.

6

Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice.

Ruskamo S, Krokengen OC, Kowal J, Nieminen T, Lehtimäki M, Raasakka A, Dandey VP, Vattulainen I, Stahlberg H, Kursula P. Ruskamo S, et al. Among authors: lehtimaki m. J Biol Chem. 2020 Jun 26;295(26):8692-8705. doi: 10.1074/jbc.RA120.013087. Epub 2020 Apr 7. J Biol Chem. 2020. PMID: 32265298 Free PMC article.

7

A novel murine in vivo model for acute hereditary angioedema attacks.

Bupp S, Whittaker M, Lehtimaki M, Park J, Dement-Brown J, Zhou ZH, Kozlowski S. Bupp S, et al. Among authors: lehtimaki m. Sci Rep. 2021 Aug 5;11(1):15924. doi: 10.1038/s41598-021-95125-0. Sci Rep. 2021. PMID: 34354123 Free PMC article.

8

Early antibody responses associated with survival in COVID19 patients.

Zhou ZH, Dharmarajan S, Lehtimaki M, Kirshner SL, Kozlowski S. Zhou ZH, et al. Among authors: lehtimaki m. PLoS Pathog. 2021 Jul 19;17(7):e1009766. doi: 10.1371/journal.ppat.1009766. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34280244 Free PMC article.

9

Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species.

Glover ZK, Wecksler A, Aryal B, Mehta S, Pegues M, Chan W, Lehtimaki M, Luo A, Sreedhara A, Rao VA. Glover ZK, et al. Among authors: lehtimaki m. MAbs. 2022 Jan-Dec;14(1):2122957. doi: 10.1080/19420862.2022.2122957. MAbs. 2022. PMID: 36151884 Free PMC article.

10

Model acetylcholinesterase-Fc fusion glycoprotein biotechnology system for the manufacture of an organophosphorus toxicant bioscavenging countermeasure.

Biel TG, Faison T, Matthews AM, Ortega-Rodriguez U, Falkowski VM, Meek E, Bush X, Flores M, Johnson S, Wu WW, Lehtimaki M, Shen RF, Agarabi C, Rao VA, Chambers JE, Ju T. Biel TG, et al. Among authors: lehtimaki m. Bioeng Transl Med. 2024 Apr 25;9(5):e10666. doi: 10.1002/btm2.10666. eCollection 2024 Sep. Bioeng Transl Med. 2024. PMID: 39553427 Free PMC article.

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