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The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.
Barreto-Torres G, Hernandez JS, Jang S, Rodríguez-Muñoz AR, Torres-Ramos CA, Basnakian AG, Javadov S. Barreto-Torres G, et al. Am J Physiol Heart Circ Physiol. 2015 Apr 1;308(7):H749-58. doi: 10.1152/ajpheart.00414.2014. Epub 2015 Jan 23. Am J Physiol Heart Circ Physiol. 2015. PMID: 25617357 Free PMC article.
Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release.
Reynolds JO, Quick AP, Wang Q, Beavers DL, Philippen LE, Showell J, Barreto-Torres G, Thuerauf DJ, Doroudgar S, Glembotski CC, Wehrens XH. Reynolds JO, et al. Among authors: barreto torres g. Int J Cardiol. 2016 Dec 15;225:371-380. doi: 10.1016/j.ijcard.2016.10.021. Epub 2016 Oct 8. Int J Cardiol. 2016. PMID: 27760414 Free PMC article.
SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity.
Quick AP, Wang Q, Philippen LE, Barreto-Torres G, Chiang DY, Beavers D, Wang G, Khalid M, Reynolds JO, Campbell HM, Showell J, McCauley MD, Scholten A, Wehrens XH. Quick AP, et al. Among authors: barreto torres g. Circ Res. 2017 Jan 6;120(1):110-119. doi: 10.1161/CIRCRESAHA.116.309977. Epub 2016 Oct 11. Circ Res. 2017. PMID: 27729468 Free PMC article.
Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction.
Quick AP, Landstrom AP, Wang Q, Beavers DL, Reynolds JO, Barreto-Torres G, Tran V, Showell J, Philippen LE, Morris SA, Skapura D, Bos JM, Pedersen SE, Pautler RG, Ackerman MJ, Wehrens XH. Quick AP, et al. Among authors: barreto torres g. JACC Basic Transl Sci. 2017 Feb;2(1):56-67. doi: 10.1016/j.jacbts.2016.11.004. JACC Basic Transl Sci. 2017. PMID: 28393127 Free PMC article.