Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule.
Takemoto Y, Slough DP, Meinke G, Katnik C, Graziano ZA, Chidipi B, Reiser M, Alhadidy MM, Ramirez R, Salvador-Montañés O, Ennis S, Guerrero-Serna G, Haburcak M, Diehl C, Cuevas J, Jalife J, Bohm A, Lin YS, Noujaim SF.
Takemoto Y, et al.
FASEB J. 2018 Apr;32(4):1778-1793. doi: 10.1096/fj.201700349R. Epub 2018 Jan 5.
FASEB J. 2018.
PMID: 29162702
Free PMC article.
Chloroquine binds the I(KACh) channel at a site formed by specific amino acids in the ion-permeation pathway, leading to decreased I(KACh) and the subsequent termination of AF.-Takemoto, Y., Slough, D. P., Meinke, G., Katnik, C., Graziano, Z. A., Chidipi, B., Reiser …
Chloroquine binds the I(KACh) channel at a site formed by specific amino acids in the ion-permeation pathway, leading to decreased I(KACh) a …