Kosoff R - Search Results

1

PAK signalling during the development and progression of cancer.

Radu M, Semenova G, Kosoff R, Chernoff J. Radu M, et al. Among authors: kosoff r. Nat Rev Cancer. 2014 Jan;14(1):13-25. doi: 10.1038/nrc3645. Nat Rev Cancer. 2014. PMID: 24505617 Free PMC article. Review.

2

A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.

Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. Arias-Romero LE, et al. Among authors: kosoff r. Oncogene. 2010 Oct 28;29(43):5839-49. doi: 10.1038/onc.2010.318. Epub 2010 Aug 16. Oncogene. 2010. PMID: 20711231 Free PMC article.

3

Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.

Kosoff R, Chow HY, Radu M, Chernoff J. Kosoff R, et al. J Biol Chem. 2013 Jan 11;288(2):974-83. doi: 10.1074/jbc.M112.422295. Epub 2012 Nov 30. J Biol Chem. 2013. PMID: 23204526 Free PMC article.

4

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

Dorrance AM, De Vita S, Radu M, Reddy PN, McGuinness MK, Harris CE, Mathieu R, Lane SW, Kosoff R, Milsom MD, Chernoff J, Williams DA. Dorrance AM, et al. Among authors: kosoff r. Blood. 2013 Mar 28;121(13):2474-82. doi: 10.1182/blood-2012-10-460709. Epub 2013 Jan 18. Blood. 2013. PMID: 23335370 Free PMC article.

5

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.

Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A. Phee H, et al. Among authors: kosoff r. Elife. 2014 May 13;3:e02270. doi: 10.7554/eLife.02270. Elife. 2014. PMID: 24843022 Free PMC article.

6

Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.

Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J. Kosoff RE, et al. Blood. 2015 May 7;125(19):2995-3005. doi: 10.1182/blood-2014-10-604504. Epub 2015 Mar 30. Blood. 2015. PMID: 25824689 Free PMC article.

7

LOV conquers (sm)All GTPases.

Kosoff R, Chernoff J. Kosoff R, et al. F1000 Biol Rep. 2010 Apr 12;2:28. doi: 10.3410/B2-28. F1000 Biol Rep. 2010. PMID: 20948805 Free PMC article.

8

Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.

Zeng Y, Broxmeyer HE, Staser K, Chitteti BR, Park SJ, Hahn S, Cooper S, Sun Z, Jiang L, Yang X, Yuan J, Kosoff R, Sandusky G, Srour EF, Chernoff J, Clapp DW. Zeng Y, et al. Among authors: kosoff r. Stem Cells. 2015 May;33(5):1630-41. doi: 10.1002/stem.1951. Stem Cells. 2015. PMID: 25586960 Free PMC article.

9

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith-Garvin JE, Okumura M, Starosvetsky E, Kosoff R, Libman E, Koretzky G, Kambayashi T, Urlaub H, Wienands J, Chernoff J, Yablonski D. Sela M, et al. Among authors: kosoff r. EMBO J. 2011 Jul 1;30(15):3160-72. doi: 10.1038/emboj.2011.213. EMBO J. 2011. PMID: 21725281 Free PMC article.

10

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.

Javvadi P, Hertan L, Kosoff R, Datta T, Kolev J, Mick R, Tuttle SW, Koumenis C. Javvadi P, et al. Among authors: kosoff r. Cancer Res. 2010 Mar 1;70(5):1941-50. doi: 10.1158/0008-5472.CAN-09-3025. Epub 2010 Feb 16. Cancer Res. 2010. PMID: 20160040 Free PMC article.

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