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Page 1
Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.
Harcken C, Riether D, Kuzmich D, Liu P, Betageri R, Ralph M, Emmanuel M, Reeves JT, Berry A, Souza D, Nelson RM, Kukulka A, Fadra TN, Zuvela-Jelaska L, Dinallo R, Bentzien J, Nabozny GH, Thomson DS. Harcken C, et al. Among authors: reeves jt. J Med Chem. 2014 Feb 27;57(4):1583-98. doi: 10.1021/jm4019178. Epub 2014 Feb 7. J Med Chem. 2014. PMID: 24506830
Start Selective and Rigidify: The Discovery Path toward a Next Generation of EGFR Tyrosine Kinase Inhibitors.
Engelhardt H, Böse D, Petronczki M, Scharn D, Bader G, Baum A, Bergner A, Chong E, Döbel S, Egger G, Engelhardt C, Ettmayer P, Fuchs JE, Gerstberger T, Gonnella N, Grimm A, Grondal E, Haddad N, Hopfgartner B, Kousek R, Krawiec M, Kriz M, Lamarre L, Leung J, Mayer M, Patel ND, Simov BP, Reeves JT, Schnitzer R, Schrenk A, Sharps B, Solca F, Stadtmüller H, Tan Z, Wunberg T, Zoephel A, McConnell DB. Engelhardt H, et al. Among authors: reeves jt. J Med Chem. 2019 Nov 27;62(22):10272-10293. doi: 10.1021/acs.jmedchem.9b01169. Epub 2019 Nov 13. J Med Chem. 2019. PMID: 31689114 Free article.
Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4.
Reeves JT, Fandrick DR, Tan Z, Song JJ, Rodriguez S, Qu B, Kim S, Niemeier O, Li Z, Byrne D, Campbell S, Chitroda A, DeCroos P, Fachinger T, Fuchs V, Gonnella NC, Grinberg N, Haddad N, Jäger B, Lee H, Lorenz JC, Ma S, Narayanan BA, Nummy LJ, Premasiri A, Roschangar F, Sarvestani M, Shen S, Spinelli E, Sun X, Varsolona RJ, Yee N, Brenner M, Senanayake CH. Reeves JT, et al. J Org Chem. 2013 Apr 19;78(8):3616-35. doi: 10.1021/jo400079z. Epub 2013 Apr 1. J Org Chem. 2013. PMID: 23544738
Zinc catalyzed and mediated asymmetric propargylation of trifluoromethyl ketones with a propargyl boronate.
Fandrick DR, Reeves JT, Bakonyi JM, Nyalapatla PR, Tan Z, Niemeier O, Akalay D, Fandrick KR, Wohlleben W, Ollenberger S, Song JJ, Sun X, Qu B, Haddad N, Sanyal S, Shen S, Ma S, Byrne D, Chitroda A, Fuchs V, Narayanan BA, Grinberg N, Lee H, Yee N, Brenner M, Senanayake CH. Fandrick DR, et al. Among authors: reeves jt. J Org Chem. 2013 Apr 19;78(8):3592-615. doi: 10.1021/jo400080y. Epub 2013 Apr 1. J Org Chem. 2013. PMID: 23544787
Carbamoyl anion addition to nitrones.
Reeves JT, Lorenc C, Camara K, Li Z, Lee H, Busacca CA, Senanayake CH. Reeves JT, et al. J Org Chem. 2014 Jun 20;79(12):5895-902. doi: 10.1021/jo500848a. Epub 2014 Jun 4. J Org Chem. 2014. PMID: 24870397
Practical Synthesis of Terminal Vinyl Fluorides.
Volchkov I, Powell BV, Zatolochnaya OV, Leung JC, Pennino S, Wu L, Gonnella NC, Bhaskararao B, Kozlowski MC, Reeves JT. Volchkov I, et al. Among authors: reeves jt. J Org Chem. 2023 Aug 4;88(15):10881-10904. doi: 10.1021/acs.joc.3c00917. Epub 2023 Jul 13. J Org Chem. 2023. PMID: 37441763 Free PMC article.
357 results