Sugimoto H - Search Results

1

Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists.

Sato K, Sugimoto H, Rikimaru K, Imoto H, Kamaura M, Negoro N, Tsujihata Y, Miyashita H, Odani T, Murata T. Sato K, et al. Among authors: sugimoto h. Bioorg Med Chem. 2014 Mar 1;22(5):1649-66. doi: 10.1016/j.bmc.2014.01.028. Epub 2014 Jan 28. Bioorg Med Chem. 2014. PMID: 24508142

2

Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.

Kamaura M, Kubo O, Sugimoto H, Noguchi N, Miyashita H, Abe S, Matsuda K, Tsujihata Y, Odani T, Iwasaki S, Murata T, Sato K. Kamaura M, et al. Among authors: sugimoto h. Bioorg Med Chem. 2021 Mar 15;34:116034. doi: 10.1016/j.bmc.2021.116034. Epub 2021 Jan 23. Bioorg Med Chem. 2021. PMID: 33548803 Free article.

3

Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist.

Fujimoto T, Rikimaru K, Fukuda K, Sugimoto H, Masuda K, Ohyabu N, Banno Y, Tokunaga N, Kawamoto T, Tomata Y, Kumagai Y, Iida M, Nagano Y, Yoneyama-Hirozane M, Shimizu Y, Sasa K, Ishikawa T, Yukitake H, Ito M, Aoyama K, Matsumoto T. Fujimoto T, et al. Among authors: sugimoto h. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462. doi: 10.1021/acsmedchemlett.1c00626. eCollection 2022 Mar 10. ACS Med Chem Lett. 2022. PMID: 35295087 Free PMC article.

4

Activation of electrophilicity of stable Y-delocalized carbamate cations in intramolecular aromatic substitution reaction: evidence for formation of diprotonated carbamates leading to generation of isocyanates.

Kurouchi H, Kawamoto K, Sugimoto H, Nakamura S, Otani Y, Ohwada T. Kurouchi H, et al. Among authors: sugimoto h. J Org Chem. 2012 Oct 19;77(20):9313-28. doi: 10.1021/jo3020566. Epub 2012 Oct 10. J Org Chem. 2012. PMID: 23025848

5

Retro-Diels-Alder reaction of 4H-1,2-benzoxazines to generate o-quinone methides: involvement of highly polarized transition states.

Sugimoto H, Nakamura S, Ohwada T. Sugimoto H, et al. J Org Chem. 2007 Dec 21;72(26):10088-95. doi: 10.1021/jo702246w. Epub 2007 Dec 1. J Org Chem. 2007. PMID: 18052075

6

Formation of 4H-1,2-benzoxazines by intramolecular cyclization of nitroalkanes. Scope of aromatic oxygen-functionalization reaction involving a nitro oxygen atom and mechanistic insights.

Nakamura S, Sugimoto H, Ohwada T. Nakamura S, et al. Among authors: sugimoto h. J Am Chem Soc. 2007 Feb 14;129(6):1724-32. doi: 10.1021/ja067682w. Epub 2007 Jan 24. J Am Chem Soc. 2007. PMID: 17249674

7

Cyclization of arylacetoacetates to indene and dihydronaphthalene derivatives in strong acids. Evidence for involvement of further protonation of O,O-diprotonated beta-ketoester, leading to enhancement of cyclization.

Kurouchi H, Sugimoto H, Otani Y, Ohwada T. Kurouchi H, et al. Among authors: sugimoto h. J Am Chem Soc. 2010 Jan 20;132(2):807-15. doi: 10.1021/ja908749u. J Am Chem Soc. 2010. PMID: 20017483

8

Superacid-catalyzed intramolecular cyclization reaction of arylcyanopropionate: geminal substitution effect on superelectrophilicity.

Nakamura S, Sugimoto H, Ohwada T. Nakamura S, et al. Among authors: sugimoto h. J Org Chem. 2008 Jun 6;73(11):4219-24. doi: 10.1021/jo800674h. Epub 2008 May 14. J Org Chem. 2008. PMID: 18476746

9

Significant response to tocilizumab in a case of immune deposits-related membranoproliferative glomerulonephritis and tubulointerstitial nephritis complicated by multicentric Castleman's disease.

Sugimoto H, Sawa N, Ikuma D, Oba Y, Mizuno H, Sekine A, Yamanouchi M, Hasegawa E, Suwabe T, Wada T, Kono K, Kinowaki K, Ohashi K, Honda K, Kanetsuna Y, Joh K, Yamaguchi Y, Ubara Y. Sugimoto H, et al. Clin Nephrol Case Stud. 2024 Dec 20;12:73-82. doi: 10.5414/CNCS111337. eCollection 2024. Clin Nephrol Case Stud. 2024. PMID: 39776937 Free PMC article.

10

Treatment of emphysematous polycystic renal infection in patients with autosomal dominant polycystic kidney disease: Feasibility and limitations of percutaneous cyst drainage.

Sugimoto H, Suwabe T, Kurihara S, Oba Y, Ikuma D, Mizuno H, Sekine A, Yamanouchi M, Miki K, Yokoyama T, Nakamura Y, Ishii Y, Wada T, Sawa N, Ubara Y. Sugimoto H, et al. Clin Nephrol Case Stud. 2024 Dec 20;12:83-89. doi: 10.5414/CNCS111450. eCollection 2024. Clin Nephrol Case Stud. 2024. PMID: 39776936 Free PMC article.

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