Sakoff JA - Search Results

1

Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.

Dyson L, Wright AD, Young KA, Sakoff JA, McCluskey A. Dyson L, et al. Among authors: sakoff ja. Bioorg Med Chem. 2014 Mar 1;22(5):1690-9. doi: 10.1016/j.bmc.2014.01.021. Epub 2014 Jan 24. Bioorg Med Chem. 2014. PMID: 24508308

2

Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity.

McCluskey A, Bowyer MC, Collins E, Sim ATR, Sakoff JA, Baldwin ML. McCluskey A, et al. Among authors: sakoff ja. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1687-90. doi: 10.1016/s0960-894x(00)00323-1. Bioorg Med Chem Lett. 2000. PMID: 10937725

3

Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.

McCluskey A, Walkom C, Bowyer MC, Ackland SP, Gardiner E, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2941-6. doi: 10.1016/s0960-894x(01)00594-7. Bioorg Med Chem Lett. 2001. PMID: 11677131

4

The first two cantharidin analogues displaying PP1 selectivity.

McCluskey A, Keane MA, Walkom CC, Bowyer MC, Sim AT, Young DJ, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Bioorg Med Chem Lett. 2002 Feb 11;12(3):391-3. doi: 10.1016/s0960-894x(01)00777-6. Bioorg Med Chem Lett. 2002. PMID: 11814804

5

Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

McCluskey A, Sim AT, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. J Med Chem. 2002 Mar 14;45(6):1151-75. doi: 10.1021/jm010066k. J Med Chem. 2002. PMID: 11881984 Review. No abstract available.

6

Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues.

Sakoff JA, Ackland SP, Baldwin ML, Keane MA, McCluskey A. Sakoff JA, et al. Invest New Drugs. 2002 Feb;20(1):1-11. doi: 10.1023/a:1014460818734. Invest New Drugs. 2002. PMID: 12003183

7

Small molecule inhibitors of serine/threonine protein phosphatases.

McCluskey A, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Mini Rev Med Chem. 2001 May;1(1):43-55. doi: 10.2174/1389557013407205. Mini Rev Med Chem. 2001. PMID: 12369990 Review.

8

The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?

McCluskey A, Ackland SP, Gardiner E, Walkom CC, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Anticancer Drug Des. 2001 Dec;16(6):291-303. Anticancer Drug Des. 2001. PMID: 12375882

9

Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines.

McCluskey A, Ackland SP, Bowyer MC, Baldwin ML, Garner J, Walkom CC, Sakoff JA. McCluskey A, et al. Among authors: sakoff ja. Bioorg Chem. 2003 Feb;31(1):68-79. doi: 10.1016/s0045-2068(02)00524-2. Bioorg Chem. 2003. PMID: 12697169

10

Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.

Sakoff JA, Howitt IJ, Ackland SP, McCluskey A. Sakoff JA, et al. Cancer Chemother Pharmacol. 2004 Mar;53(3):225-32. doi: 10.1007/s00280-003-0730-9. Epub 2003 Nov 25. Cancer Chemother Pharmacol. 2004. PMID: 14648018

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