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ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium.
Gaudreault N, Kumar N, Posada JM, Stephens KB, Reyes de Mochel NS, Eberlé D, Olivas VR, Kim RY, Harms MJ, Johnson S, Messina LM, Rapp JH, Raffai RL. Gaudreault N, et al. Among authors: raffai rl. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):264-72. doi: 10.1161/ATVBAHA.111.238964. Epub 2011 Nov 3. Arterioscler Thromb Vasc Biol. 2012. PMID: 22053073 Free PMC article.
Inducible ApoE gene repair in hypomorphic ApoE mice deficient in the low-density lipoprotein receptor promotes atheroma stabilization with a human-like lipoprotein profile.
Eberlé D, Luk FS, Kim RY, Olivas VR, Kumar N, Posada JM, Li K, Gaudreault N, Rapp JH, Raffai RL. Eberlé D, et al. Among authors: raffai rl. Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1759-67. doi: 10.1161/ATVBAHA.112.300605. Epub 2013 Jun 20. Arterioscler Thromb Vasc Biol. 2013. PMID: 23788760 Free PMC article.
Hyperglycemia impairs atherosclerosis regression in mice.
Gaudreault N, Kumar N, Olivas VR, Eberlé D, Stephens K, Raffai RL. Gaudreault N, et al. Among authors: raffai rl. Am J Pathol. 2013 Dec;183(6):1981-1992. doi: 10.1016/j.ajpath.2013.08.019. Epub 2013 Oct 8. Am J Pathol. 2013. PMID: 24113453 Free PMC article.
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H. Mattis AN, et al. Among authors: raffai rl. Hepatology. 2015 Jan;61(1):141-52. doi: 10.1002/hep.27379. Epub 2014 Nov 24. Hepatology. 2015. PMID: 25131933 Free PMC article.
68 results