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HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH. Rotblat B, et al. Among authors: metzler m. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516159 Free PMC article.
Life without huntingtin: normal differentiation into functional neurons.
Metzler M, Chen N, Helgason CD, Graham RK, Nichol K, McCutcheon K, Nasir J, Humphries RK, Raymond LA, Hayden MR. Metzler M, et al. J Neurochem. 1999 Mar;72(3):1009-18. doi: 10.1046/j.1471-4159.1999.0721009.x. J Neurochem. 1999. PMID: 10037472 Free article.
Huntingtin is required for normal hematopoiesis.
Metzler M, Helgason CD, Dragatsis I, Zhang T, Gan L, Pineault N, Zeitlin SO, Humphries RK, Hayden MR. Metzler M, et al. Hum Mol Genet. 2000 Feb 12;9(3):387-94. doi: 10.1093/hmg/9.3.387. Hum Mol Genet. 2000. PMID: 10655548
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease.
Graham RK, Pouladi MA, Joshi P, Lu G, Deng Y, Wu NP, Figueroa BE, Metzler M, André VM, Slow EJ, Raymond L, Friedlander R, Levine MS, Leavitt BR, Hayden MR. Graham RK, et al. Among authors: metzler m. J Neurosci. 2009 Feb 18;29(7):2193-204. doi: 10.1523/JNEUROSCI.5473-08.2009. J Neurosci. 2009. PMID: 19228972 Free PMC article.
621 results