Savinainen JR - Search Results

1

1,2-Dihydro-2-oxopyridine-3-carboxamides: the C-5 substituent is responsible for functionality switch at CB2 cannabinoid receptor.

Lucchesi V, Parkkari T, Savinainen JR, Malfitano AM, Allarà M, Bertini S, Castelli F, Del Carlo S, Laezza C, Ligresti A, Saccomanni G, Bifulco M, Di Marzo V, Macchia M, Manera C. Lucchesi V, et al. Among authors: savinainen jr. Eur J Med Chem. 2014 Mar 3;74:524-32. doi: 10.1016/j.ejmech.2013.10.070. Epub 2014 Jan 21. Eur J Med Chem. 2014. PMID: 24518874

2

Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives.

Parkkari T, Savinainen JR, Rauhala AL, Tolonen TL, Nevalainen T, Laitinen JT, Gynther J, Järvinen T. Parkkari T, et al. Among authors: savinainen jr. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3231-4. doi: 10.1016/j.bmcl.2004.03.093. Bioorg Med Chem Lett. 2004. PMID: 15149681

3

Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.

Savinainen JR, Kokkola T, Salo OM, Poso A, Järvinen T, Laitinen JT. Savinainen JR, et al. Br J Pharmacol. 2005 Jul;145(5):636-45. doi: 10.1038/sj.bjp.0706230. Br J Pharmacol. 2005. PMID: 15852035 Free PMC article.

4

Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor.

Salo OM, Raitio KH, Savinainen JR, Nevalainen T, Lahtela-Kakkonen M, Laitinen JT, Järvinen T, Poso A. Salo OM, et al. Among authors: savinainen jr. J Med Chem. 2005 Nov 17;48(23):7166-71. doi: 10.1021/jm050565b. J Med Chem. 2005. PMID: 16279774

5

Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE).

Parkkari T, Salo OM, Huttunen KM, Savinainen JR, Laitinen JT, Poso A, Nevalainen T, Järvinen T. Parkkari T, et al. Among authors: savinainen jr. Bioorg Med Chem. 2006 Apr 15;14(8):2850-8. doi: 10.1016/j.bmc.2005.12.007. Epub 2006 Jan 5. Bioorg Med Chem. 2006. PMID: 16403642

6

3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.

Salo OM, Savinainen JR, Parkkari T, Nevalainen T, Lahtela-Kakkonen M, Gynther J, Laitinen JT, Järvinen T, Poso A. Salo OM, et al. Among authors: savinainen jr. J Med Chem. 2006 Jan 26;49(2):554-66. doi: 10.1021/jm0505157. J Med Chem. 2006. PMID: 16420041

7

Alpha-methylated derivatives of 2-arachidonoyl glycerol: synthesis, CB1 receptor activity, and enzymatic stability.

Parkkari T, Myllymäki M, Savinainen JR, Saario SM, Castillo-Meléndez JA, Laitinen JT, Nevalainen T, Koskinen AM, Järvinen T. Parkkari T, et al. Among authors: savinainen jr. Bioorg Med Chem Lett. 2006 May 1;16(9):2437-40. doi: 10.1016/j.bmcl.2006.01.101. Epub 2006 Feb 8. Bioorg Med Chem Lett. 2006. PMID: 16466915

8

Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists.

Raitio KH, Savinainen JR, Vepsäläinen J, Laitinen JT, Poso A, Järvinen T, Nevalainen T. Raitio KH, et al. Among authors: savinainen jr. J Med Chem. 2006 Mar 23;49(6):2022-7. doi: 10.1021/jm050879z. J Med Chem. 2006. PMID: 16539390

9

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide.

Parkkari T, Savinainen JR, Raitio KH, Saario SM, Matilainen L, Sirviö T, Laitinen JT, Nevalainen T, Niemi R, Järvinen T. Parkkari T, et al. Among authors: savinainen jr. Bioorg Med Chem. 2006 Aug 1;14(15):5252-8. doi: 10.1016/j.bmc.2006.03.051. Epub 2006 Apr 27. Bioorg Med Chem. 2006. PMID: 16644227

10

Chiral 1,3,4-oxadiazol-2-ones as highly selective FAAH inhibitors.

Patel JZ, Parkkari T, Laitinen T, Kaczor AA, Saario SM, Savinainen JR, Navia-Paldanius D, Cipriano M, Leppänen J, Koshevoy IO, Poso A, Fowler CJ, Laitinen JT, Nevalainen T. Patel JZ, et al. Among authors: savinainen jr. J Med Chem. 2013 Nov 14;56(21):8484-96. doi: 10.1021/jm400923s. Epub 2013 Oct 22. J Med Chem. 2013. PMID: 24083878

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