Meng T - Search Results

1

The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.

DeMong D, Dai X, Hwa J, Miller M, Lin SI, Kang L, Stamford A, Greenlee W, Yu W, Wong M, Lavey B, Kozlowski J, Zhou G, Yang DY, Patel B, Soriano A, Zhai Y, Sondey C, Zhang H, Lachowicz J, Grotz D, Cox K, Morrison R, Andreani T, Cao Y, Liang M, Meng T, McNamara P, Wong J, Bradley P, Feng KI, Belani J, Chen P, Dai P, Gauuan J, Lin P, Zhao H. DeMong D, et al. Among authors: meng t. J Med Chem. 2014 Mar 27;57(6):2601-10. doi: 10.1021/jm401858f. Epub 2014 Feb 26. J Med Chem. 2014. PMID: 24527772

2

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.

Arasappan A, Bennett F, Bogen SL, Venkatraman S, Blackman M, Chen KX, Hendrata S, Huang Y, Huelgas RM, Nair L, Padilla AI, Pan W, Pike R, Pinto P, Ruan S, Sannigrahi M, Velazquez F, Vibulbhan B, Wu W, Yang W, Saksena AK, Girijavallabhan V, Shih NY, Kong J, Meng T, Jin Y, Wong J, McNamara P, Prongay A, Madison V, Piwinski JJ, Cheng KC, Morrison R, Malcolm B, Tong X, Ralston R, Njoroge FG. Arasappan A, et al. Among authors: meng t. ACS Med Chem Lett. 2010 Feb 15;1(2):64-9. doi: 10.1021/ml9000276. eCollection 2010 May 13. ACS Med Chem Lett. 2010. PMID: 24900178 Free PMC article.

3

Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors.

Hu J, Tian CQ, Damaneh MS, Li Y, Cao D, Lv K, Yu T, Meng T, Chen D, Wang X, Chen L, Li J, Song SS, Huan XJ, Qin L, Shen J, Wang YQ, Miao ZH, Xiong B. Hu J, et al. Among authors: meng t. J Med Chem. 2019 Sep 26;62(18):8642-8663. doi: 10.1021/acs.jmedchem.9b01094. Epub 2019 Sep 16. J Med Chem. 2019. PMID: 31490070

4

Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists.

Gao L, Li M, Meng T, Peng H, Xie X, Zhang Y, Jin Y, Wang X, Zou L, Shen J. Gao L, et al. Among authors: meng t. Eur J Med Chem. 2011 Nov;46(11):5310-6. doi: 10.1016/j.ejmech.2011.08.030. Epub 2011 Sep 1. Eur J Med Chem. 2011. PMID: 21937154

5

Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor.

Hu J, Wang Y, Li Y, Xu L, Cao D, Song S, Damaneh MS, Wang X, Meng T, Chen YL, Shen J, Miao Z, Xiong B. Hu J, et al. Among authors: meng t. Eur J Med Chem. 2017 Sep 8;137:176-195. doi: 10.1016/j.ejmech.2017.05.049. Epub 2017 May 27. Eur J Med Chem. 2017. PMID: 28586718

6

Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.

Du Y, Li Q, Xiong B, Hui X, Wang X, Feng Y, Meng T, Hu D, Zhang D, Wang M, Shen J. Du Y, et al. Among authors: meng t. Bioorg Med Chem. 2010 Jun 15;18(12):4255-68. doi: 10.1016/j.bmc.2010.04.092. Epub 2010 May 24. Bioorg Med Chem. 2010. PMID: 20510622

7

Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach.

Meng T, Wang J, Peng H, Fang G, Li M, Xiong B, Xie X, Zhang Y, Wang X, Shen J. Meng T, et al. Eur J Med Chem. 2010 Mar;45(3):1133-9. doi: 10.1016/j.ejmech.2009.12.018. Epub 2009 Dec 16. Eur J Med Chem. 2010. PMID: 20047779

8

Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.

Meng T, Zhang D, Xie Z, Yu T, Wu S, Wyder L, Regenass U, Hilpert K, Huang M, Geng M, Shen J. Meng T, et al. J Med Chem. 2014 Dec 11;57(23):9832-43. doi: 10.1021/jm5010144. Epub 2014 Nov 26. J Med Chem. 2014. PMID: 25383915

9

CCLab--a multi-objective genetic algorithm based combinatorial library design software and an application for histone deacetylase inhibitor design.

Fang G, Xue M, Su M, Hu D, Li Y, Xiong B, Ma L, Meng T, Chen Y, Li J, Li J, Shen J. Fang G, et al. Among authors: meng t. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4540-5. doi: 10.1016/j.bmcl.2012.05.123. Epub 2012 Jun 7. Bioorg Med Chem Lett. 2012. PMID: 22738629

10

Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.

An W, Wang W, Yu T, Zhang Y, Miao Z, Meng T, Shen J. An W, et al. Among authors: meng t. Eur J Med Chem. 2016 Apr 13;112:367-372. doi: 10.1016/j.ejmech.2016.02.004. Epub 2016 Feb 5. Eur J Med Chem. 2016. PMID: 26927488

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