Liefaard L - Search Results

1

The Dynamics of Compound, Transcript, and Protein Effects After Treatment With 2OMePS Antisense Oligonucleotides in mdx Mice.

Verhaart IE, van Vliet-van den Dool L, Sipkens JA, de Kimpe SJ, Kolfschoten IG, van Deutekom JC, Liefaard L, Ridings JE, Hood SR, Aartsma-Rus A. Verhaart IE, et al. Among authors: liefaard l. Mol Ther Nucleic Acids. 2014 Feb 18;3(2):e148. doi: 10.1038/mtna.2014.1. Mol Ther Nucleic Acids. 2014. PMID: 24549299 Free PMC article.

2

Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study.

Voit T, Topaloglu H, Straub V, Muntoni F, Deconinck N, Campion G, De Kimpe SJ, Eagle M, Guglieri M, Hood S, Liefaard L, Lourbakos A, Morgan A, Nakielny J, Quarcoo N, Ricotti V, Rolfe K, Servais L, Wardell C, Wilson R, Wright P, Kraus JE. Voit T, et al. Among authors: liefaard l. Lancet Neurol. 2014 Oct;13(10):987-96. doi: 10.1016/S1474-4422(14)70195-4. Epub 2014 Sep 7. Lancet Neurol. 2014. PMID: 25209738 Clinical Trial.

3

Pharmacokinetics and safety of single doses of drisapersen in non-ambulant subjects with Duchenne muscular dystrophy: results of a double-blind randomized clinical trial.

Flanigan KM, Voit T, Rosales XQ, Servais L, Kraus JE, Wardell C, Morgan A, Dorricott S, Nakielny J, Quarcoo N, Liefaard L, Drury T, Campion G, Wright P. Flanigan KM, et al. Among authors: liefaard l. Neuromuscul Disord. 2014 Jan;24(1):16-24. doi: 10.1016/j.nmd.2013.09.004. Epub 2013 Sep 11. Neuromuscul Disord. 2014. PMID: 24321374 Free PMC article. Clinical Trial.

4

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Intravenous Dose of Miridesap in Healthy Japanese Subjects.

Ino H, Doi Y, Liefaard L, Cookson L, Chen C, Itoh H, Igarashi H, Nakano A. Ino H, et al. Among authors: liefaard l. Clin Pharmacol Drug Dev. 2019 Jul;8(5):612-618. doi: 10.1002/cpdd.631. Epub 2018 Dec 17. Clin Pharmacol Drug Dev. 2019. PMID: 30556959 Clinical Trial.

5

Randomized Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2831781 in Healthy Japanese and White Participants.

Liefaard L, Hajduk E, van den Berg F, Panoilia E, Bouma G, Lisi E, Srinivasan N, Cui Y, Gross AS, Tarzi R, Marks DJB. Liefaard L, et al. Clin Pharmacol Drug Dev. 2022 Nov;11(11):1284-1293. doi: 10.1002/cpdd.1165. Epub 2022 Sep 11. Clin Pharmacol Drug Dev. 2022. PMID: 36088650 Clinical Trial.

6

Quantifying the Effectiveness of Dose Individualization by Simulation for a Drug With Moderate Pharmacokinetic Variability.

Liefaard L, Chen C. Liefaard L, et al. Ther Drug Monit. 2015 Oct;37(5):641-8. doi: 10.1097/FTD.0000000000000194. Ther Drug Monit. 2015. PMID: 26378372

7

Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis.

Richards DB, Cookson LM, Barton SV, Liefaard L, Lane T, Hutt DF, Ritter JM, Fontana M, Moon JC, Gillmore JD, Wechalekar A, Hawkins PN, Pepys MB. Richards DB, et al. Among authors: liefaard l. Sci Transl Med. 2018 Jan 3;10(422):eaan3128. doi: 10.1126/scitranslmed.aan3128. Sci Transl Med. 2018. PMID: 29298867

8

Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap.

Richards D, Bamford M, Liefaard L, Haque N, Lewis G, Storey J, Fernando D, Kumar S, Thompson D, Holmes DS. Richards D, et al. Among authors: liefaard l. Br J Pharmacol. 2020 Apr;177(8):1853-1864. doi: 10.1111/bph.14956. Epub 2020 Feb 11. Br J Pharmacol. 2020. PMID: 31877231 Free PMC article.

9

Time-to-Event Modeling of Left- or Right-Censored Toxicity Data in Nonclinical Drug Toxicology.

Berges A, Cerou M, Sahota T, Liefaard L, Ambery C, Zamuner S, Chen C, Hénin E. Berges A, et al. Among authors: liefaard l. Toxicol Sci. 2018 Sep 1;165(1):50-60. doi: 10.1093/toxsci/kfy122. Toxicol Sci. 2018. PMID: 29788384

10

Depletion of LAG-3⁺ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781.

Ellis J, J B Marks D, Srinivasan N, Barrett C, Hopkins TG, Richards A, Fuhr R, Albayaty M, Coenen M, Liefaard L, Leavens K, Nevin KL, Tang S, Hughes SA, Fortunato L, Edwards K, Cui Y, Anselm R, Delves CJ, Charles E, Feeney M, Webb TM, Brett SJ, Schmidt TS, Stone J, Savage COS, Wisniacki N, Tarzi RM. Ellis J, et al. Among authors: liefaard l. Clin Pharmacol Ther. 2021 May;109(5):1293-1303. doi: 10.1002/cpt.2091. Epub 2020 Nov 24. Clin Pharmacol Ther. 2021. PMID: 33113155 Free PMC article. Clinical Trial.

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