Nelson M - Search Results

1

Folate-vinca alkaloid conjugates for cancer therapy: a structure-activity relationship.

Leamon CP, Vlahov IR, Reddy JA, Vetzel M, Santhapuram HK, You F, Bloomfield A, Dorton R, Nelson M, Kleindl P, Vaughn JF, Westrick E. Leamon CP, et al. Among authors: nelson m. Bioconjug Chem. 2014 Mar 19;25(3):560-8. doi: 10.1021/bc400441s. Epub 2014 Mar 11. Bioconjug Chem. 2014. PMID: 24564229

2

Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications.

Leamon CP, Reddy JA, Klein PJ, Vlahov IR, Dorton R, Bloomfield A, Nelson M, Westrick E, Parker N, Bruna K, Vetzel M, Gehrke M, Nicoson JS, Messmann RA, LoRusso PM, Sausville EA. Leamon CP, et al. Among authors: nelson m. J Pharmacol Exp Ther. 2011 Feb;336(2):336-43. doi: 10.1124/jpet.110.175109. Epub 2010 Oct 26. J Pharmacol Exp Ther. 2011. PMID: 20978169

3

Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs.

Reddy JA, Dorton R, Bloomfield A, Nelson M, Vetzel M, Guan J, Leamon CP. Reddy JA, et al. Among authors: nelson m. Clin Cancer Res. 2014 Apr 15;20(8):2104-14. doi: 10.1158/1078-0432.CCR-13-2423. Epub 2014 Jan 15. Clin Cancer Res. 2014. PMID: 24429878

4

High Levels of Expression of P-glycoprotein/Multidrug Resistance Protein Result in Resistance to Vintafolide.

Guertin AD, O'Neil J, Stoeck A, Reddy JA, Cristescu R, Haines BB, Hinton MC, Dorton R, Bloomfield A, Nelson M, Vetzel M, Lejnine S, Nebozhyn M, Zhang T, Loboda A, Picard KL, Schmidt EV, Dussault I, Leamon CP. Guertin AD, et al. Among authors: nelson m. Mol Cancer Ther. 2016 Aug;15(8):1998-2008. doi: 10.1158/1535-7163.MCT-15-0950. Epub 2016 Jun 2. Mol Cancer Ther. 2016. PMID: 27256377

5

Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates.

Vlahov IR, Qi L, Kleindl PJ, Santhapuram HK, Felten A, Parham GL, Wang K, You F, Vaughn JF, Hahn SJ, Klein HF, Vetzel M, Reddy JA, Nelson M, Nicoson J, Leamon CP. Vlahov IR, et al. Among authors: nelson m. Bioconjug Chem. 2017 Dec 20;28(12):2921-2931. doi: 10.1021/acs.bioconjchem.7b00476. Epub 2017 Dec 6. Bioconjug Chem. 2017. PMID: 29211454

6

Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic.

Reddy JA, Dorton R, Bloomfield A, Nelson M, Dircksen C, Vetzel M, Kleindl P, Santhapuram H, Vlahov IR, Leamon CP. Reddy JA, et al. Among authors: nelson m. Sci Rep. 2018 Jun 12;8(1):8943. doi: 10.1038/s41598-018-27320-5. Sci Rep. 2018. PMID: 29895863 Free PMC article.

7

Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate.

Leamon CP, Reddy JA, Bloomfield A, Dorton R, Nelson M, Vetzel M, Kleindl P, Hahn S, Wang K, Vlahov IR. Leamon CP, et al. Among authors: nelson m. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813. doi: 10.1021/acs.bioconjchem.9b00335. Epub 2019 May 22. Bioconjug Chem. 2019. PMID: 31075200

8

Detecting Functional and Accessible Folate Receptor Expression in Cancer and Polycystic Kidneys.

Chu H, Shillingford JM, Reddy JA, Westrick E, Nelson M, Wang EZ, Parker N, Felten AE, Vaughn JF, Xu LC, Lu YJ, Vlahov IR, Leamon CP. Chu H, et al. Among authors: nelson m. Mol Pharm. 2019 Sep 3;16(9):3985-3995. doi: 10.1021/acs.molpharmaceut.9b00624. Epub 2019 Aug 13. Mol Pharm. 2019. PMID: 31356752

9

Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent.

Reddy JA, Nelson M, Dircksen C, Vetzel M, Johnson T, Cross V, Westrick E, Qi L, Hahn S, Santhapuram HK, Parham G, Wang K, Vaughn JF, Felten A, Pugh M, Lu J, Klein P, Vlahov IR, Leamon CP. Reddy JA, et al. Among authors: nelson m. Sci Rep. 2020 Jul 29;10(1):12772. doi: 10.1038/s41598-020-69682-9. Sci Rep. 2020. PMID: 32728172 Free PMC article.

10

Development and validation of a UPLC-MS/MS method for the novel folate-targeted small molecule drug conjugate EC1456 and its metabolites in tumor homogenates from mice.

Rao SI, Pugh M, Nelson M, Reddy JA, Klein PJ, Leamon CP. Rao SI, et al. Among authors: nelson m. J Pharm Biomed Anal. 2016 Apr 15;122:148-56. doi: 10.1016/j.jpba.2016.01.049. Epub 2016 Jan 25. J Pharm Biomed Anal. 2016. PMID: 26855286

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