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Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.
De Bellis F, Carafa V, Conte M, Rotili D, Petraglia F, Matarese F, Françoijs KJ, Ablain J, Valente S, Castellano R, Goubard A, Collette Y, Mandoli A, Martens JH, de Thé H, Nebbioso A, Mai A, Stunnenberg HG, Altucci L. De Bellis F, et al. Among authors: de the h. Cancer Res. 2014 Apr 15;74(8):2328-39. doi: 10.1158/0008-5472.CAN-13-2568. Epub 2014 Feb 24. Cancer Res. 2014. PMID: 24566867
Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.
Altucci L, Rossin A, Hirsch O, Nebbioso A, Vitoux D, Wilhelm E, Guidez F, De Simone M, Schiavone EM, Grimwade D, Zelent A, de Thé H, Gronemeyer H. Altucci L, et al. Among authors: de the h, de simone m. Cancer Res. 2005 Oct 1;65(19):8754-65. doi: 10.1158/0008-5472.CAN-04-3569. Cancer Res. 2005. PMID: 16204045
8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation.
Jiao B, Ren ZH, Liu P, Chen LJ, Shi JY, Dong Y, Ablain J, Shi L, Gao L, Hu JP, Ren RB, de Thé H, Chen Z, Chen SJ. Jiao B, et al. Among authors: de the h. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3495-500. doi: 10.1073/pnas.1222863110. Epub 2013 Feb 4. Proc Natl Acad Sci U S A. 2013. PMID: 23382200 Free PMC article.
How animal models of leukaemias have already benefited patients.
Ablain J, Nasr R, Zhu J, Bazarbachi A, Lallemand-Breittenbach V, de Thé H. Ablain J, et al. Among authors: de the h. Mol Oncol. 2013 Apr;7(2):224-31. doi: 10.1016/j.molonc.2013.01.006. Epub 2013 Feb 11. Mol Oncol. 2013. PMID: 23453906 Free PMC article. Review.
289 results