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Page 1
β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells.
Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F. Keerthivasan S, et al. Among authors: bentrem dj. Sci Transl Med. 2014 Feb 26;6(225):225ra28. doi: 10.1126/scitranslmed.3007607. Sci Transl Med. 2014. PMID: 24574339 Free PMC article.
In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction.
Blatner NR, Bonertz A, Beckhove P, Cheon EC, Krantz SB, Strouch M, Weitz J, Koch M, Halverson AL, Bentrem DJ, Khazaie K. Blatner NR, et al. Among authors: bentrem dj. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6430-5. doi: 10.1073/pnas.0913683107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308560 Free PMC article.
Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.
Cheon EC, Khazaie K, Khan MW, Strouch MJ, Krantz SB, Phillips J, Blatner NR, Hix LM, Zhang M, Dennis KL, Salabat MR, Heiferman M, Grippo PJ, Munshi HG, Gounaris E, Bentrem DJ. Cheon EC, et al. Among authors: bentrem dj. Cancer Res. 2011 Mar 1;71(5):1627-36. doi: 10.1158/0008-5472.CAN-10-1923. Epub 2011 Jan 7. Cancer Res. 2011. PMID: 21216893
The significant role of mast cells in cancer.
Khazaie K, Blatner NR, Khan MW, Gounari F, Gounaris E, Dennis K, Bonertz A, Tsai FN, Strouch MJ, Cheon E, Phillips JD, Beckhove P, Bentrem DJ. Khazaie K, et al. Among authors: bentrem dj. Cancer Metastasis Rev. 2011 Mar;30(1):45-60. doi: 10.1007/s10555-011-9286-z. Cancer Metastasis Rev. 2011. PMID: 21287360 Review.
Expression of RORγt marks a pathogenic regulatory T cell subset in human colon cancer.
Blatner NR, Mulcahy MF, Dennis KL, Scholtens D, Bentrem DJ, Phillips JD, Ham S, Sandall BP, Khan MW, Mahvi DM, Halverson AL, Stryker SJ, Boller AM, Singal A, Sneed RK, Sarraj B, Ansari MJ, Oft M, Iwakura Y, Zhou L, Bonertz A, Beckhove P, Gounari F, Khazaie K. Blatner NR, et al. Among authors: bentrem dj. Sci Transl Med. 2012 Dec 12;4(164):164ra159. doi: 10.1126/scitranslmed.3004566. Sci Transl Med. 2012. PMID: 23241743 Free PMC article.
PI3K/AKT signaling is essential for communication between tissue-infiltrating mast cells, macrophages, and epithelial cells in colitis-induced cancer.
Khan MW, Keshavarzian A, Gounaris E, Melson JE, Cheon EC, Blatner NR, Chen ZE, Tsai FN, Lee G, Ryu H, Barrett TA, Bentrem DJ, Beckhove P, Khazaie K. Khan MW, et al. Among authors: bentrem dj. Clin Cancer Res. 2013 May 1;19(9):2342-54. doi: 10.1158/1078-0432.CCR-12-2623. Epub 2013 Mar 13. Clin Cancer Res. 2013. PMID: 23487439 Free PMC article.
Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation.
Gounaris E, Heiferman MJ, Heiferman JR, Shrivastav M, Vitello D, Blatner NR, Knab LM, Phillips JD, Cheon EC, Grippo PJ, Khazaie K, Munshi HG, Bentrem DJ. Gounaris E, et al. Among authors: bentrem dj. PLoS One. 2015 Mar 6;10(3):e0121402. doi: 10.1371/journal.pone.0121402. eCollection 2015. PLoS One. 2015. PMID: 25747113 Free PMC article.
319 results