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Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.
Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G. Fantini D, et al. Among authors: tell g. Nucleic Acids Res. 2010 Dec;38(22):8239-56. doi: 10.1093/nar/gkq691. Epub 2010 Aug 10. Nucleic Acids Res. 2010. PMID: 20699270 Free PMC article.
Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G. Lirussi L, et al. Among authors: tell g. Mol Biol Cell. 2012 Oct;23(20):4079-96. doi: 10.1091/mbc.E12-04-0299. Epub 2012 Aug 23. Mol Biol Cell. 2012. PMID: 22918947 Free PMC article.
622 results