IFN regulatory factor 1 restricts hepatitis E virus replication by activating STAT1 to induce antiviral IFN-stimulated genes.
Xu L, Zhou X, Wang W, Wang Y, Yin Y, Laan LJ, Sprengers D, Metselaar HJ, Peppelenbosch MP, Pan Q.
Xu L, et al. Among authors: zhou x.
FASEB J. 2016 Oct;30(10):3352-3367. doi: 10.1096/fj.201600356R. Epub 2016 Jun 21.
FASEB J. 2016.
PMID: 27328944
We demonstrated that IRF1 effectively inhibits HEV replication through the activation of the JAK-STAT pathway, and the subsequent transcription of antiviral ISGs, but independent of IFN production.-Xu, L., Zhou, X., Wang, W., Wang, Y., Yin, Y., van der Laan, L. J. W …
We demonstrated that IRF1 effectively inhibits HEV replication through the activation of the JAK-STAT pathway, and the subsequent transcript …