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Direct measurement of local oxygen concentration in the bone marrow of live animals.
Spencer JA, Ferraro F, Roussakis E, Klein A, Wu J, Runnels JM, Zaher W, Mortensen LJ, Alt C, Turcotte R, Yusuf R, Côté D, Vinogradov SA, Scadden DT, Lin CP. Spencer JA, et al. Among authors: yusuf r. Nature. 2014 Apr 10;508(7495):269-73. doi: 10.1038/nature13034. Epub 2014 Mar 2. Nature. 2014. PMID: 24590072 Free PMC article.
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.
Gurumurthy S, Xie SZ, Alagesan B, Kim J, Yusuf RZ, Saez B, Tzatsos A, Ozsolak F, Milos P, Ferrari F, Park PJ, Shirihai OS, Scadden DT, Bardeesy N. Gurumurthy S, et al. Nature. 2010 Dec 2;468(7324):659-63. doi: 10.1038/nature09572. Nature. 2010. PMID: 21124451 Free PMC article.
Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning.
Saez B, Ferraro F, Yusuf RZ, Cook CM, Yu VW, Pardo-Saganta A, Sykes SM, Palchaudhuri R, Schajnovitz A, Lotinun S, Lymperi S, Mendez-Ferrer S, Toro RD, Day R, Vasic R, Acharya SS, Baron R, Lin CP, Yamaguchi Y, Wagers AJ, Scadden DT. Saez B, et al. Among authors: yusuf rz. Blood. 2014 Nov 6;124(19):2937-47. doi: 10.1182/blood-2014-08-593426. Epub 2014 Sep 8. Blood. 2014. PMID: 25202142 Free PMC article.
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.
Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT. Sykes SM, et al. Among authors: yusuf r. Cell. 2011 Sep 2;146(5):697-708. doi: 10.1016/j.cell.2011.07.032. Cell. 2011. PMID: 21884932 Free PMC article.
188 results