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Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3.
Hall J, Zhang Z, Wang D, Bhattacharya S, Alcantara M, Liang Y, Swiderski P, Forman S, Kwak L, Vaidehi N, Kortylewski M. Hall J, et al. Among authors: kortylewski m. bioRxiv [Preprint]. 2023 Aug 3:2023.08.01.551552. doi: 10.1101/2023.08.01.551552. bioRxiv. 2023. Update in: Mol Ther Nucleic Acids. 2024 Feb 05;35(1):102137. doi: 10.1016/j.omtn.2024.102137 PMID: 37577590 Free PMC article. Updated. Preprint.
Local CpG- Stat3 siRNA treatment improves antitumor effects of immune checkpoint inhibitors.
Zhang C, Huang R, Ren L, Song J, Kortylewski M, Swiderski P, Forman S, Yu H. Zhang C, et al. Among authors: kortylewski m. bioRxiv [Preprint]. 2023 Aug 19:2023.08.17.553571. doi: 10.1101/2023.08.17.553571. bioRxiv. 2023. Update in: Mol Ther Nucleic Acids. 2024 Oct 09;35(4):102357. doi: 10.1016/j.omtn.2024.102357 PMID: 37645787 Free PMC article. Updated. Preprint.
Role of Stat3 in suppressing anti-tumor immunity.
Kortylewski M, Yu H. Kortylewski M, et al. Curr Opin Immunol. 2008 Apr;20(2):228-33. doi: 10.1016/j.coi.2008.03.010. Epub 2008 May 12. Curr Opin Immunol. 2008. PMID: 18479894 Free PMC article. Review.
Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.
Ma Y, Kowolik CM, Swiderski PM, Kortylewski M, Yu H, Horne DA, Jove R, Caballero OL, Simpson AJ, Lee FT, Pillay V, Scott AM. Ma Y, et al. Among authors: kortylewski m. ACS Chem Biol. 2011 Sep 16;6(9):962-70. doi: 10.1021/cb200176v. Epub 2011 Jul 26. ACS Chem Biol. 2011. PMID: 21766840 Free PMC article.
Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape.
Nechaev S, Gao C, Moreira D, Swiderski P, Jozwiak A, Kowolik CM, Zhou J, Armstrong B, Raubitschek A, Rossi JJ, Kortylewski M. Nechaev S, et al. Among authors: kortylewski m. J Control Release. 2013 Sep 28;170(3):307-15. doi: 10.1016/j.jconrel.2013.06.007. Epub 2013 Jun 15. J Control Release. 2013. PMID: 23777886 Free PMC article.
102 results