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Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.
Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK. Ilyinskii PO, et al. Among authors: johnston lp. Vaccine. 2014 May 19;32(24):2882-95. doi: 10.1016/j.vaccine.2014.02.027. Epub 2014 Mar 1. Vaccine. 2014. PMID: 24593999 Free PMC article.
Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance.
Maldonado RA, LaMothe RA, Ferrari JD, Zhang AH, Rossi RJ, Kolte PN, Griset AP, O'Neil C, Altreuter DH, Browning E, Johnston L, Farokhzad OC, Langer R, Scott DW, von Andrian UH, Kishimoto TK. Maldonado RA, et al. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E156-65. doi: 10.1073/pnas.1408686111. Epub 2014 Dec 29. Proc Natl Acad Sci U S A. 2015. PMID: 25548186 Free PMC article.
Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles.
Kishimoto TK, Ferrari JD, LaMothe RA, Kolte PN, Griset AP, O'Neil C, Chan V, Browning E, Chalishazar A, Kuhlman W, Fu FN, Viseux N, Altreuter DH, Johnston L, Maldonado RA. Kishimoto TK, et al. Nat Nanotechnol. 2016 Oct;11(10):890-899. doi: 10.1038/nnano.2016.135. Epub 2016 Aug 1. Nat Nanotechnol. 2016. PMID: 27479756
TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25.
Thompson EA, Ols S, Miura K, Rausch K, Narum DL, Spångberg M, Juraska M, Wille-Reece U, Weiner A, Howard RF, Long CA, Duffy PE, Johnston L, O'Neil CP, Loré K. Thompson EA, et al. JCI Insight. 2018 May 17;3(10):e120692. doi: 10.1172/jci.insight.120692. eCollection 2018 May 17. JCI Insight. 2018. PMID: 29769448 Free PMC article.
ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia.
Ilyinskii PO, Michaud AM, Rizzo GL, Roy CJ, Leung SS, Elkins SL, Capela T, Chowdhury A, Li L, Chandler RJ, Manoli I, Andres-Mateos E, Johnston LPM, Vandenberghe LH, Venditti CP, Kishimoto TK. Ilyinskii PO, et al. Among authors: johnston lpm. Mol Ther Methods Clin Dev. 2021 Jul 16;22:279-292. doi: 10.1016/j.omtm.2021.06.015. eCollection 2021 Sep 10. Mol Ther Methods Clin Dev. 2021. PMID: 34485611 Free PMC article.
11 results